Literature DB >> 20085326

Chemical delivery system of metaiodobenzylguanidine (MIBG) to the central nervous system.

Fabienne Gourand1, Guillaume Mercey, Méziane Ibazizène, Olivier Tirel, Joël Henry, Vincent Levacher, Cécile Perrio, Louisa Barré.   

Abstract

The aim of the present investigation was to apply a chemical delivery system (CDS) to MIBG (4) with the purpose of delivering this drug to the CNS. Compound 4 has been linked to a 1,4-dihydroquinoline moiety in order to achieve its CNS penetration, and here we report the synthesis to link 4 to the chemical delivery system and the radiosynthesis with carbon-11 of the "CDS-4 entity". After iv injection into rats of the [(11)C]CDS-4, the follow-up study of the radioactivity distribution in blood samples and brain homogenates and the analysis by HPLC and LC-MS/MS have confirmed the release of 4 into the CNS.

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Year:  2010        PMID： 20085326     DOI： 10.1021/jm901550z

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  2 in total

1.  Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.

Authors:  Swati S More; Melissa Itsara; Xiaodong Yang; Ethan G Geier; Michelle K Tadano; Youngho Seo; Henry F Vanbrocklin; William A Weiss; Sabine Mueller; Daphne A Haas-Kogan; Steven G Dubois; Katherine K Matthay; Kathleen M Giacomini
Journal:  Clin Cancer Res       Date:  2011-03-18       Impact factor: 12.531

2.  Chemical Delivery System of MIBG to the Central Nervous System: Synthesis, 11C-Radiosynthesis, and in Vivo Evaluation.

Authors:  Fabienne Gourand; Delphine Patin; Axelle Henry; Méziane Ibazizène; Martine Dhilly; Fabien Fillesoye; Olivier Tirel; Mihaela-Liliana Tintas; Cyril Papamicaël; Vincent Levacher; Louisa Barré
Journal:  ACS Med Chem Lett       Date:  2019-02-15       Impact factor: 4.345
  2 in total

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