AIM: To determine rates of cerebral atrophy in individuals with symptoms of memory loss but no objective cognitive impairment (SNCI) and their association with future cognitive decline. METHODS: Thirty-two SNCI subjects, 16 with mild cognitive impairment (MCI) and 27 control subjects had clinical assessment and magnetic resonance imaging at baseline and 1 year later. Rates of whole brain atrophy (WBA), hippocampal atrophy (HA) and ventricular enlargement (VE) were measured. Our outcome was clinical diagnosis at 2 years after entry into the study. RESULTS: The MCI group had greater rates of WBA, HA and VE than both controls and SNCI subjects. As a group SNCI subjects did not have significantly greater rates of atrophy than the controls. However, SNCI subjects who progressed to MCI or dementia had increased rates of atrophy compared with those who remained stable. DISCUSSION: Individuals with memory complaints but no objective memory deficits, who progress to MCI or dementia, have increased rates of cerebral atrophy.
AIM: To determine rates of cerebral atrophy in individuals with symptoms of memory loss but no objective cognitive impairment (SNCI) and their association with future cognitive decline. METHODS: Thirty-two SNCI subjects, 16 with mild cognitive impairment (MCI) and 27 control subjects had clinical assessment and magnetic resonance imaging at baseline and 1 year later. Rates of whole brain atrophy (WBA), hippocampal atrophy (HA) and ventricular enlargement (VE) were measured. Our outcome was clinical diagnosis at 2 years after entry into the study. RESULTS: The MCI group had greater rates of WBA, HA and VE than both controls and SNCI subjects. As a group SNCI subjects did not have significantly greater rates of atrophy than the controls. However, SNCI subjects who progressed to MCI or dementia had increased rates of atrophy compared with those who remained stable. DISCUSSION: Individuals with memory complaints but no objective memory deficits, who progress to MCI or dementia, have increased rates of cerebral atrophy.
Authors: Carol Y Cheung; Win Lee Edwin Wong; Saima Hilal; Cheuk Ni Kan; Bibek Gyanwali; Yih Chung Tham; Leopold Schmetterer; Dejiang Xu; Mong Li Lee; Wynne Hsu; Narayanaswamy Venketasubramanian; Boon Yeow Tan; Tien Yin Wong; Christopher P L H Chen Journal: Brain Commun Date: 2022-08-17
Authors: Kate E Macdonald; Jonathan W Bartlett; Kelvin K Leung; Sebastien Ourselin; Josephine Barnes Journal: Alzheimer Dis Assoc Disord Date: 2013 Apr-Jun Impact factor: 2.703
Authors: S Karama; M E Bastin; C Murray; N A Royle; L Penke; S Muñoz Maniega; A J Gow; J Corley; M del C Valdés Hernández; J D Lewis; M-É Rousseau; C Lepage; V Fonov; D L Collins; T Booth; P Rioux; T Sherif; R Adalat; J M Starr; A C Evans; J M Wardlaw; I J Deary Journal: Mol Psychiatry Date: 2013-06-04 Impact factor: 15.992