Literature DB >> 20084350

[Spread of hyperbaric local anesthetics in a spinal canal model. The influence of Trendelenburg position and spinal configuration].

V C Valencia Chavez1, H Baumann, J Biscoping.   

Abstract

BACKGROUND: The influence of Trendelenburg positions and variations in spinal canal configuration on the spread of hyperbaric spinal anesthetics was examined in two models of the subarachnoid space.
METHODS: Both models included simulations of the spinal cord, filum terminale and cerebrospinal fluid. Model I had a straight shape, thus omitting replications of lumbar lordosis and thoracic kyphosis. It allowed the evaluation of fluid dynamics and the spread of 0.5% hyperbaric bupivacaine and 4% hyperbaric mepivacaine in 0° (supine position), 5° and 10° head-down tilt positions. Model II included reconstructions of average adult spinal curvatures for closer analysis of the intrathecal spread of 0.5% hyperbaric bupivacaine in 0°, 5°, 10° and 15° head-down tilt positions. Concentration gradients within the artificial cerebrospinal fluid were calculated using a digital image processing technique. Data from both model investigations were compared to elaborate the effect of varying lumbar lordosis angles.
RESULTS: Model I: Only the 5° head-down tilt caused a significant difference in maximum spread of both local anesthetics. Model II: A 15° head-down tilt resulted in the local anesthetic solution spilling over lumbar lordosis and effusing into the thoracic areas. With increasing degree of head-down tilt, the local anesthetic solution was also detectable in ventral parts of the spinal canal cross-section.
CONCLUSIONS: Diffusion processes represent the decisive factor for distribution patterns of hyperbaric anesthetics in the supine position. Only the 5° head-down tilt demonstrated an influence of specific gravity. When tilted 10° head-down gravitation prevailed over differences in density. A 15° head-down tilt is a precondition for the mobilization of sacrally pooled local anesthetic. Data comparison of both model investigations showed that the extent of spread depends more on initial bidirectional distribution of the local anesthetic than on increasing flow rate due to the slope of lumbar lordosis.

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Year:  2010        PMID: 20084350     DOI: 10.1007/s00101-009-1661-6

Source DB:  PubMed          Journal:  Anaesthesist        ISSN: 0003-2417            Impact factor:   1.041


  28 in total

Review 1.  Intrathecal drug spread.

Authors:  G Hocking; J A W Wildsmith
Journal:  Br J Anaesth       Date:  2004-06-25       Impact factor: 9.166

2.  Influence of injection rate of hyperbaric bupivacaine on spinal block in parturients: a randomized trial.

Authors:  Sudha Indu Singh; Patricia K Morley-Forster; Mohammed Shamsah; Ron Butler
Journal:  Can J Anaesth       Date:  2007-04       Impact factor: 5.063

3.  Trendelenburg position with hip flexion as a rescue strategy to increase spinal anaesthetic level after spinal block.

Authors:  J-T Kim; J-K Shim; S-H Kim; C-W Jung; J-H Bahk
Journal:  Br J Anaesth       Date:  2007-02-05       Impact factor: 9.166

4.  Spinal anesthesia and lumbar lordosis.

Authors:  M R Logan; G B Drummond
Journal:  Anesth Analg       Date:  1988-04       Impact factor: 5.108

Review 5.  Distribution of local anesthetic solutions within the subarachnoid space.

Authors:  N M Greene
Journal:  Anesth Analg       Date:  1985-07       Impact factor: 5.108

6.  The effect of head-down tilt on arterial blood pressure after spinal anesthesia.

Authors:  M Miyabe; A Namiki
Journal:  Anesth Analg       Date:  1993-03       Impact factor: 5.108

7.  [The effect of the injection speed on the blockade characteristics of hyperbaric bupivacaine and tetracaine in spinal anesthesia].

Authors:  R Janik; W Dick; M Stanton-Hicks
Journal:  Reg Anaesth       Date:  1989-07

8.  The effect of head-down tilt position on arterial blood pressure after spinal anesthesia for cesarean delivery.

Authors:  M Miyabe; S Sato
Journal:  Reg Anesth       Date:  1997 May-Jun

9.  In vitro modeling of spinal anesthesia. A digital video image processing technique and its application to catheter characterization.

Authors:  R A Robinson; S F Stewart; M R Myers; L F Lien; J R Rinaldi; J L Swisher; K Drasner
Journal:  Anesthesiology       Date:  1994-10       Impact factor: 7.892

10.  Effect of late posture change on the level of spinal anaesthesia with plain bupivacaine.

Authors:  L Niemi; M Tuominen; M Pitkänen; P H Rosenberg
Journal:  Br J Anaesth       Date:  1993-12       Impact factor: 9.166

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