Literature DB >> 200835

Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway.

F Karst, F Lacroute.   

Abstract

Thermosensitive mutants, auxotrophic for ergosterol synthesis, have been isolated, analyzed genetically and their enzymatic deficiencies investigated. These mutants were classified into seven unlinked complementation groups. These groupes lack the following enzymatic activities: squalene epoxidase (erg 1), 2,3-oxidosqualene-lanosterol cyclase (erg 7), phosphomevalonic kinase (erg 8), mevalonic kinase (erg12) and squalene synthetase (erg 9, erg 10, erg 11).

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Year:  1977        PMID： 200835     DOI： 10.1007/bf00571282

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  26 in total

1.  Studies on the biosynthesis of cholesterol. 9. Formation of phosphorylated derivatives of mevalonic acid in liver-enzyme preparations.

Authors:  A DE WAARD; G POPJAK
Journal:  Biochem J       Date:  1959-11       Impact factor: 3.857

2.  Biosynthesis of terpenes. VII. Isopentenyl pyrophosphate isomerase.

Authors:  B W AGRANOFF; H EGGERER; U HENNING; F LYNEN
Journal:  J Biol Chem       Date:  1960-02       Impact factor: 5.157

3.  Anaerobic nutrition of Saccharomyces cerevisiae. I. Ergosterol requirement for growth in a defined medium.

Authors:  A A ANDREASEN; T J B STIER
Journal:  J Cell Comp Physiol       Date:  1953-02

4.  Yeast mutant requiring only a sterol as growth supplement.

Authors:  F Karst; F Lacroute
Journal:  Biochem Biophys Res Commun       Date:  1974-07-10       Impact factor: 3.575

5.  Isolation of pleiotropic yeast mutants requiring ergosterol for growth.

Authors:  F Karst; F Lacroute
Journal:  Biochem Biophys Res Commun       Date:  1973-06-08       Impact factor: 3.575

6.  Selective killing of vegetative cells in sporulated yeast cultures by exposure to diethyl ether.

Authors:  I W Dawes; I D Hardie
Journal:  Mol Gen Genet       Date:  1974

7.  Yeast mutants requiring ergosterol as only lipid supplement.

Authors:  E G Gollub; P Trocha; P K Liu; D B Sprinson
Journal:  Biochem Biophys Res Commun       Date:  1974-01-23       Impact factor: 3.575

8.  Studies on squalene epoxidase of rat liver.

Authors:  S Yamamoto; K Bloch
Journal:  J Biol Chem       Date:  1970-04-10       Impact factor: 5.157

9.  Comparative properties of 2,3-oxidosqualene-lanosterol cyclase from yeast and liver.

Authors:  I Shechter; F W Sweat; K Bloch
Journal:  Biochim Biophys Acta       Date:  1970-12-16

10.  Genetic and physiological control of serine and glycine biosynthesis in Saccharomyces.

Authors:  R Ulane; M Ogur
Journal:  J Bacteriol       Date:  1972-01       Impact factor: 3.490
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  31 in total

1.  Isolation and properties of yeast mutants affected in farnesyl diphosphate synthetase.

Authors:  C Chambon; V Ladeveze; A Oulmouden; M Servouse; F Karst
Journal:  Curr Genet       Date:  1990-07       Impact factor: 3.886

2.  Extensive in vivo metabolite-protein interactions revealed by large-scale systematic analyses.

Authors:  Xiyan Li; Tara A Gianoulis; Kevin Y Yip; Mark Gerstein; Michael Snyder
Journal:  Cell       Date:  2010-10-28       Impact factor: 41.582

3.  Nucleotide sequence of the ERG12 gene of Saccharomyces cerevisiae encoding mevalonate kinase.

Authors:  A Oulmouden; F Karst
Journal:  Curr Genet       Date:  1991-01       Impact factor: 3.886

4.  Experimental Evolution Identifies Adaptive Aneuploidy as a Mechanism of Fluconazole Resistance in Candida auris.

Authors:  Jian Bing; Tianren Hu; Qiushi Zheng; José F Muñoz; Christina A Cuomo; Guanghua Huang
Journal:  Antimicrob Agents Chemother       Date:  2020-12-16       Impact factor: 5.191

5.  Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.

Authors:  D Gachotte; S E Sen; J Eckstein; R Barbuch; M Krieger; B D Ray; M Bard
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

6.  Phospholipid synthesis in S. cerevisiae strain GL7 grown without unsaturated fatty acid supplements.

Authors:  T M Buttke; R Reynolds; A L Pyle
Journal:  Lipids       Date:  1982-05       Impact factor: 1.880

7.  Aspects of sterol metabolism in the yeast Saccharomyces cerevisiae and in Phytophthora.

Authors:  L W Parks; C McLean-Bowen; C K Bottema; F R Taylor; R Gonzales; B W Jensen; J R Ramp
Journal:  Lipids       Date:  1982-03       Impact factor: 1.880

8.  Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase.

Authors:  Y H Tsay; G W Robinson
Journal:  Mol Cell Biol       Date:  1991-02       Impact factor: 4.272

9.  Sterol uptake induced by an impairment of pyridoxal phosphate synthesis in Saccharomyces cerevisiae: cloning and sequencing of the PDX3 gene encoding pyridoxine (pyridoxamine) phosphate oxidase.

Authors:  A Loubbardi; C Marcireau; F Karst; M Guilloton
Journal:  J Bacteriol       Date:  1995-04       Impact factor: 3.490

10.  Isolation and primary structure of the ERG9 gene of Saccharomyces cerevisiae encoding squalene synthetase.

Authors:  M Fegueur; L Richard; A D Charles; F Karst
Journal:  Curr Genet       Date:  1991-11       Impact factor: 3.886
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