Literature DB >> 20083398

TLR signalling regulated antigen presentation in dendritic cells.

Colin Watts1, Michele A West, Rossana Zaru.   

Abstract

Recent evidence suggests that TLR signalling in dendritic cells (DCs) transiently enhances antigen endocytosis and autophagy, augments the assembly of key antigen transport and processing systems, qualitatively modulates protein translation and induces a temporary cessation of DC motility. These rapid changes require activation of the MAP kinases, PI3-kinase and downstream signalling pathways and are observed in both myeloid DC and, with variations on the theme, in plasmacytoid DC. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20083398     DOI： 10.1016/j.coi.2009.12.005

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  65 in total

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