AIMS: To determine if hyperglycemia on admission correlates to infarct size measured by single-photon emission computed tomography (SPECT) in patients with acute ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). METHODS: We evaluated 347 STEMI patients who underwent primary PCI. Infarct size was determined by SPECT on Day 5. The population was divided into: hyperglycemia (glycemia on admission >11mmol/L) or non-hyperglycemia (<or=11mmol/L) regardless of diabetic status. RESULTS: 61 (17.6%) patients presented with hyperglycemia on admission. There were no significant differences in baseline characteristics or in PCI characteristics between the two groups. Final TIMI 3 flow was achieved in 81.7% of patients with hyperglycemia vs 85.7% of patients with non-hyperglycemia (p=0.43). The infarct size was larger in the hyperglycemia group (6 [2-14]% vs 8.5 [3-18.25]%; p=0.016). A multivariate linear regression analysis showed that hyperglycemia on admission was an independent predictor of infarct size at Day 5 post-MI (p=0.004). CONCLUSION: In patients with STEMI treated with primary PCI, hyperglycemia on admission is associated with larger infarct size determined by SPECT.
AIMS: To determine if hyperglycemia on admission correlates to infarct size measured by single-photon emission computed tomography (SPECT) in patients with acute ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). METHODS: We evaluated 347 STEMI patients who underwent primary PCI. Infarct size was determined by SPECT on Day 5. The population was divided into: hyperglycemia (glycemia on admission >11mmol/L) or non-hyperglycemia (<or=11mmol/L) regardless of diabetic status. RESULTS: 61 (17.6%) patients presented with hyperglycemia on admission. There were no significant differences in baseline characteristics or in PCI characteristics between the two groups. Final TIMI 3 flow was achieved in 81.7% of patients with hyperglycemia vs 85.7% of patients with non-hyperglycemia (p=0.43). The infarct size was larger in the hyperglycemia group (6 [2-14]% vs 8.5 [3-18.25]%; p=0.016). A multivariate linear regression analysis showed that hyperglycemia on admission was an independent predictor of infarct size at Day 5 post-MI (p=0.004). CONCLUSION: In patients with STEMI treated with primary PCI, hyperglycemia on admission is associated with larger infarct size determined by SPECT.
Authors: Joanna Gierach; Marcin Gierach; Iwona Świątkiewicz; Marek Woźnicki; Grzegorz Grześk; Adam Sukiennik; Marek Koziñski; Jacek Kubica Journal: Heart Vessels Date: 2014-12-25 Impact factor: 2.037
Authors: Sinead Brophy; Roxanne Cooksey; Michael B Gravenor; Clive Weston; Steven M Macey; Gareth John; Rhys Williams; Ronan A Lyons Journal: BMC Public Health Date: 2010-06-14 Impact factor: 3.295
Authors: Danijela Trifunovic; Sanja Stankovic; Dragana Sobic-Saranovic; Jelena Marinkovic; Marija Petrovic; Dejan Orlic; Branko Beleslin; Marko Banovic; Bosiljka Vujisic-Tesic; Milan Petrovic; Ivana Nedeljkovic; Jelena Stepanovic; Ana Djordjevic-Dikic; Milorad Tesic; Nina Djukanovic; Olga Petrovic; Olga Vasovic; Emilija Nestorovic; Jelena Kostic; Arsen Ristic; Miodrag Ostojic Journal: Cardiovasc Diabetol Date: 2014-04-05 Impact factor: 9.951