BACKGROUND: Transforming growth factor beta (TGF-beta) may be a crucial regulator of cardiac remodeling. We investigated the association between the TGF-beta gene polymorphisms and left ventricular structure. METHODS: A total of 658 hypertensive subjects were genotyped for the TGF-beta1 T869C and TGF-beta3 (rs3917187 and rs4252338) polymorphisms. RESULTS: TGF-beta3 rs3917187 AA homozygotes had, while accounting for covariates, greater left ventricular end-systolic (LVESD, P=0.004) and end-diastolic dimension (LVEDD, P=0.007) than G allele carriers. Moreover, left ventricular mass index (LVMI) in AA genotype was 123.0+/-3.1g/m(2) significantly higher than that in AG (114.6+/-1.6g/m(2)) and GG (115.4+/-2.1g/m(2), P=0.03) genotypes. In multivariate regression analysis, TGF-beta3 rs3917187 genotype as an independent predictor had statistically significant effects on LVESD (beta=0.164, P=0.002), LVEDD (beta=0.172, P=0.003) and LVMI (beta=0.136, P=0.016), respectively. In further analyses, we observed a significant interaction between the rs3917187 and alcohol intake in relation to LVESD (P(int)=0.04) and left ventricular fractional shortening (LVFSH, P(int)=0.012). However, no relationship could be found between left ventricular parameters and the T869C or the rs4252338. CONCLUSION: The present results demonstrated that the TGF-beta3 rs3917187 polymorphism was associated with left ventricular structure, and had an interactive influence with alcohol on LVESD and LVFSH in hypertensive subjects. 2009 Elsevier B.V. All rights reserved.
BACKGROUND:Transforming growth factor beta (TGF-beta) may be a crucial regulator of cardiac remodeling. We investigated the association between the TGF-beta gene polymorphisms and left ventricular structure. METHODS: A total of 658 hypertensive subjects were genotyped for the TGF-beta1T869C and TGF-beta3 (rs3917187 and rs4252338) polymorphisms. RESULTS:TGF-beta3rs3917187 AA homozygotes had, while accounting for covariates, greater left ventricular end-systolic (LVESD, P=0.004) and end-diastolic dimension (LVEDD, P=0.007) than G allele carriers. Moreover, left ventricular mass index (LVMI) in AA genotype was 123.0+/-3.1g/m(2) significantly higher than that in AG (114.6+/-1.6g/m(2)) and GG (115.4+/-2.1g/m(2), P=0.03) genotypes. In multivariate regression analysis, TGF-beta3rs3917187 genotype as an independent predictor had statistically significant effects on LVESD (beta=0.164, P=0.002), LVEDD (beta=0.172, P=0.003) and LVMI (beta=0.136, P=0.016), respectively. In further analyses, we observed a significant interaction between the rs3917187 and alcohol intake in relation to LVESD (P(int)=0.04) and left ventricular fractional shortening (LVFSH, P(int)=0.012). However, no relationship could be found between left ventricular parameters and the T869C or the rs4252338. CONCLUSION: The present results demonstrated that the TGF-beta3rs3917187 polymorphism was associated with left ventricular structure, and had an interactive influence with alcohol on LVESD and LVFSH in hypertensive subjects. 2009 Elsevier B.V. All rights reserved.
Authors: Thomas Doetschman; Joey V Barnett; Raymond B Runyan; Todd D Camenisch; Ronald L Heimark; Henk L Granzier; Simon J Conway; Mohamad Azhar Journal: Cell Tissue Res Date: 2011-09-28 Impact factor: 5.249
Authors: Bradford E Hall; Umesh D Wankhade; Joanne E Konkel; Karthik Cherukuri; Chandrasekharam N Nagineni; Kathleen C Flanders; Praveen R Arany; Wanjun Chen; Sushil G Rane; Ashok B Kulkarni Journal: J Biol Chem Date: 2013-09-20 Impact factor: 5.157
Authors: Thomas Doetschman; Teodora Georgieva; Hongqi Li; Thomas D Reed; Christina Grisham; Jacqueline Friel; Mark A Estabrook; Connie Gard; L P Sanford; Mohamad Azhar Journal: Genesis Date: 2012-01-06 Impact factor: 2.487
Authors: David Della-Morte; Ashley Beecham; Tatjana Rundek; Liyong Wang; Mark S McClendon; Susan Slifer; Susan H Blanton; Marco R Di Tullio; Ralph L Sacco Journal: BMC Med Genet Date: 2011-07-26 Impact factor: 2.103