| Literature DB >> 20082953 |
Rudolf A Rupec1, Susanne Boneberger, Thomas Ruzicka.
Abstract
The pathophysiology of atopic dermatitis is still under discussion. Although it is widely accepted that environmental factors and a genetic predisposition are essential, the role of the innate and adaptive immune system and the functional cascade of the cells involved is still unclear. A concept that integrates all immune cells as equally essential has allure. In addition, barrier abnormalities due to mutations of the gene coding for filaggrin and down-regulation of antimicrobial peptides, such as LL-37 and beta-defensins 2 and 3, were very recently found to be relevant for the pathogenesis of atopic dermatitis. Copyright 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20082953 DOI： 10.1016/j.clindermatol.2009.04.004
Source DB: PubMed Journal: Clin Dermatol ISSN： 0738-081X Impact factor: 3.541