Literature DB >> 20082856

Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization.

Jiyun Lee1, Jianzhou Wang, Michael Torbenson, You Lu, Qiong Z Liu, Shibo Li.   

Abstract

We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14 approximately q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases. Published by Elsevier Inc.

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Year:  2010        PMID： 20082856     DOI： 10.1016/j.cancergencyto.2009.09.005

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  10 in total

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