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Literature DB >> 20081886

Could aging human skin use a connective tissue growth factor boost to increase collagen content?

Noelynn Oliver¹, Mark Sternlicht, Karin Gerritsen, Roel Goldschmeding.

Abstract

The roles of connective tissue growth factor (CTGF) and transforming growth factor-beta (TGF-beta), both well-known collagen production stimulators, were examined in skin aging. Aged skin and fibroblasts exhibited a coordinate decrease in CTGF, TGF-beta, and type I procollagen expression and content. CTGF knockdown and TGF-beta blockade in normal dermal fibroblasts reduced procollagen expression, whereas overexpressing CTGF increased procollagen by a TGF-beta/Smad signaling-dependent mechanism without involving Smad2/3.

Entities: Gene Species

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Year: 2010 PMID： 20081886 DOI： 10.1038/jid.2009.331

Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551

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Cited

16 in total

1. Effect of Chimpi, dried citrus peel, on aquaporin-3 expression in HaCaT human epidermal keratinocytes.

Authors: Nobutomo Ikarashi; Miho Kaneko; Daigo Wakana; Yui Shinozaki; Keito Tabata; Yui Nishinaka; Ryotaro Yoshida; Tomofumi Watanabe; Nobuyuki Wakui; Risako Kon; Hiroyasu Sakai; Junzo Kamei; Tomoo Hosoe
Journal: Mol Biol Rep Date: 2022-08-28 Impact factor: 2.742

2. ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene.

Authors: Maria Chatzifrangkeskou; Caroline Le Dour; Wei Wu; John P Morrow; Leroy C Joseph; Maud Beuvin; Fusako Sera; Shunichi Homma; Nicolas Vignier; Nathalie Mougenot; Gisèle Bonne; Kenneth E Lipson; Howard J Worman; Antoine Muchir
Journal: Hum Mol Genet Date: 2016-04-30 Impact factor: 6.150

3. The Growth Differentiation Factor 11 is Involved in Skin Fibroblast Ageing and is Induced by a Preparation of Peptides and Sugars Derived from Plant Cell Cultures.

Authors: Annalisa Tito; Ani Barbulova; Claudia Zappelli; Marilisa Leone; Menotti Ruvo; Flavia Anna Mercurio; Angela Chambery; Rosita Russo; Maria Gabriella Colucci; Fabio Apone
Journal: Mol Biotechnol Date: 2019-03 Impact factor: 2.695

4. P38 pathway as a key downstream signal of connective tissue growth factor to regulate metastatic potential in non-small-cell lung cancer.

Authors: Shinichiro Kato; Satoru Yokoyama; Yoshihiro Hayakawa; Luhui Li; Yusuke Iwakami; Hiroaki Sakurai; Ikuo Saiki
Journal: Cancer Sci Date: 2016-09-01 Impact factor: 6.716

5. Panax ginseng total protein promotes proliferation and secretion of collagen in NIH/3T3 cells by activating extracellular signal-related kinase pathway.

Authors: Xuenan Chen; Manying Wang; Xiaohao Xu; Jianzeng Liu; Bing Mei; Pingping Fu; Daqing Zhao; Liwei Sun
Journal: J Ginseng Res Date: 2017-03-01 Impact factor: 6.060

10. Enhancing structural support of the dermal microenvironment activates fibroblasts, endothelial cells, and keratinocytes in aged human skin in vivo.

Authors: Taihao Quan; Frank Wang; Yuan Shao; Laure Rittié; Wei Xia; Jeffrey S Orringer; John J Voorhees; Gary J Fisher
Journal: J Invest Dermatol Date: 2012-10-25 Impact factor: 8.551

Could aging human skin use a connective tissue growth factor boost to increase collagen content?

1. Effect of Chimpi, dried citrus peel, on aquaporin-3 expression in HaCaT human epidermal keratinocytes.

2. ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene.

3. The Growth Differentiation Factor 11 is Involved in Skin Fibroblast Ageing and is Induced by a Preparation of Peptides and Sugars Derived from Plant Cell Cultures.

4. P38 pathway as a key downstream signal of connective tissue growth factor to regulate metastatic potential in non-small-cell lung cancer.

5. Panax ginseng total protein promotes proliferation and secretion of collagen in NIH/3T3 cells by activating extracellular signal-related kinase pathway.

6. Relationship between Aging-Related Skin Dryness and Aquaporins.

7. TGF-β-independent CTGF induction regulates cell adhesion mediated drug resistance by increasing collagen I in HCC.

8. IGF-1 modulates gene expression of proteins involved in inflammation, cytoskeleton, and liver architecture.

9. CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis.

10. Enhancing structural support of the dermal microenvironment activates fibroblasts, endothelial cells, and keratinocytes in aged human skin in vivo.