Literature DB >> 20080948

Differential regulation of p53 target genes: it's (core promoter) elementary.

Nathan P Gomes1, Joaquín M Espinosa.   

Abstract

p53 is a pleiotropic transcription factor driving a flexible transcriptional program that mediates disparate cellular responses to stress, including cell cycle arrest and apoptosis. The mechanisms by which p53 differentially regulates its diverse target genes remain poorly understood. In this issue of Genes & Development, Morachis and colleagues (pp. 135-147) demonstrate the critical role of core promoter elements at p53 target loci, in that they dictate differential RNA polymerase II recruitment and activity in a p53-autonomous fashion.

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Year:  2010        PMID： 20080948      PMCID： PMC2807345          DOI： 10.1101/gad.1893610

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  26 in total

1.  Analysis of p53-regulated gene expression patterns using oligonucleotide arrays.

Authors:  R Zhao; K Gish; M Murphy; Y Yin; D Notterman; W H Hoffman; E Tom; D H Mack; A J Levine
Journal:  Genes Dev       Date:  2000-04-15       Impact factor: 11.361

2.  Enhancer-promoter specificity mediated by DPE or TATA core promoter motifs.

Authors:  J E Butler; J T Kadonaga
Journal:  Genes Dev       Date:  2001-10-01       Impact factor: 11.361

Review 3.  The RNA polymerase II core promoter.

Authors:  Stephen T Smale; James T Kadonaga
Journal:  Annu Rev Biochem       Date:  2003-03-19       Impact factor: 23.643

4.  p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage.

Authors:  Joaquín M Espinosa; Ramiro E Verdun; Beverly M Emerson
Journal:  Mol Cell       Date:  2003-10       Impact factor: 17.970

5.  Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.

Authors:  Carol Imbriano; Aymone Gurtner; Fabienne Cocchiarella; Silvia Di Agostino; Valentina Basile; Monica Gostissa; Matthias Dobbelstein; Giannino Del Sal; Giulia Piaggio; Roberto Mantovani
Journal:  Mol Cell Biol       Date:  2005-05       Impact factor: 4.272

6.  Regulation of the p53 transcriptional response by structurally diverse core promoters.

Authors:  José M Morachis; Christopher M Murawsky; Beverly M Emerson
Journal:  Genes Dev       Date:  2009-12-29       Impact factor: 11.361

7.  Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53.

Authors:  L Resnick-Silverman; S St Clair; M Maurer; K Zhao; J J Manfredi
Journal:  Genes Dev       Date:  1998-07-15       Impact factor: 11.361

Review 8.  The ASPP family: deciding between life and death after DNA damage.

Authors:  Elizabeth A Slee; Xin Lu
Journal:  Toxicol Lett       Date:  2003-04-04       Impact factor: 4.372

9.  Kinetics of p53 binding to promoter sites in vivo.

Authors:  S T Szak; D Mays; J A Pietenpol
Journal:  Mol Cell Biol       Date:  2001-05       Impact factor: 4.272

10.  p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.

Authors:  K Oda; H Arakawa; T Tanaka; K Matsuda; C Tanikawa; T Mori; H Nishimori; K Tamai; T Tokino; Y Nakamura; Y Taya
Journal:  Cell       Date:  2000-09-15       Impact factor: 41.582
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  13 in total

1.  Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes.

Authors:  Nathan P Gomes; Joaquín M Espinosa
Journal:  Cell Cycle       Date:  2010-09-13       Impact factor: 4.534

2.  SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing.

Authors:  Yupeng Chen; Lirong Zhang; Katherine A Jones
Journal:  Genes Dev       Date:  2011-04-01       Impact factor: 11.361

3.  Distinct p53 genomic binding patterns in normal and cancer-derived human cells.

Authors:  Krassimira Botcheva; Sean R McCorkle; W R McCombie; John J Dunn; Carl W Anderson
Journal:  Cell Cycle       Date:  2011-12-15       Impact factor: 4.534

4.  Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression.

Authors:  Jie Ding; Gernot Polier; Rebecca Köhler; Marco Giaisi; Peter H Krammer; Min Li-Weber
Journal:  J Biol Chem       Date:  2011-11-15       Impact factor: 5.157

5.  Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass spectrometry.

Authors:  Jenna Scotcher; David J Clarke; Stefan K Weidt; C Logan Mackay; Ted R Hupp; Peter J Sadler; Pat R R Langridge-Smith
Journal:  J Am Soc Mass Spectrom       Date:  2011-02-24       Impact factor: 3.109

6.  Soluble guanylyl cyclase α1 and p53 cytoplasmic sequestration and down-regulation in prostate cancer.

Authors:  Changmeng Cai; Chen-Lin Hsieh; Shuai Gao; Archana Kannan; Meenakshi Bhansali; Kumara Govardhan; Ranendra Dutta; Lirim Shemshedini
Journal:  Mol Endocrinol       Date:  2011-12-15

7.  TFIIB dephosphorylation links transcription inhibition with the p53-dependent DNA damage response.

Authors:  Jayasha Shandilya; Yuming Wang; Stefan G E Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-30       Impact factor: 11.205

8.  The Toll-like receptor gene family is integrated into human DNA damage and p53 networks.

Authors:  Daniel Menendez; Maria Shatz; Kathleen Azzam; Stavros Garantziotis; Michael B Fessler; Michael A Resnick
Journal:  PLoS Genet       Date:  2011-03-31       Impact factor: 5.917

9.  Disruption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway.

Authors:  R Koster; H Timmer-Bosscha; R Bischoff; J A Gietema; S de Jong
Journal:  Cell Death Dis       Date:  2011-04-21       Impact factor: 8.469

10.  Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters.

Authors:  S K Mungamuri; S Wang; J J Manfredi; W Gu; S A Aaronson
Journal:  Oncogene       Date:  2014-07-14       Impact factor: 9.867
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