| Literature DB >> 20079873 |
Manuela Garibaldi1, Manuel J Rodríguez-Ortega, Francesca Mandanici, Angela Cardaci, Angelina Midiri, Salvatore Papasergi, Orazio Gambadoro, Vittorio Cavallari, Giuseppe Teti, Concetta Beninati.
Abstract
Pili of gram-positive bacteria are key virulence factors and their subunits are considered excellent vaccine candidates. Streptococcus suis is an emerging zoonotic agent that can cause epidemics of life-threatening infections in humans, but the functional role or immunoprotective potential of its pilus components have not been studied yet. Using a selective proteomics approach, we have identified a surface protein of serotype 2 S. suis showing features of an ancillary pilus subunit, as evidenced by bioinformatics analysis, immunoblot and immunoelectron microscopy. Immunization with recombinant fragments of this protein, designated herein as PAPI-2b, markedly protected mice from systemic S. suis infection. (c) 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20079873 DOI： 10.1016/j.vaccine.2010.01.009
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641