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Literature DB >> 20079872

ERp57, a multifunctional endoplasmic reticulum resident oxidoreductase.

Abstract

ERp57 is a 58-kDa thiol oxidoreductase and a member of the protein disulfide isomerase (PDI)-like family. ERp57 is highly similar to other PDI family members in terms of amino acid sequence and structural/functional domain organization; however, it possesses some distinctive structural features that dictate its unique functions in the cell. This protein plays an important role in endoplasmic reticulum quality control of newly synthesized glycoproteins, is critical in major histocompatability complex (MHC) class I assembly and regulates gene expression. Studies on ERp57-deficient mice indicate that the protein is critical during embryonic development. The protein has been implicated in human pathologies including cancer and Alzheimer's disease. Copyright 2010 Elsevier Ltd. All rights reserved.

Entities: Chemical Disease Gene Species

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Year: 2010 PMID： 20079872 DOI： 10.1016/j.biocel.2010.01.009

Source DB: PubMed Journal: Int J Biochem Cell Biol ISSN： 1357-2725 Impact factor: 5.085

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Cited

43 in total

1. ERp57 as a novel cellular factor controlling prion protein biosynthesis: Therapeutic potential of protein disulfide isomerases.

Authors: Martin Sepulveda; Pablo Rozas; Claudio Hetz; Danilo B Medinas
Journal: Prion Date: 2016 Impact factor: 3.931

2. Proteomic identification of carbonylated proteins in the kidney of trichloroethene-exposed MRL+/+ mice.

Authors: Xiuzhen Fan; Gangduo Wang; Robert D English; M Firoze Khan
Journal: Toxicol Mech Methods Date: 2013-10-07 Impact factor: 2.987

3. Nsp1α of Porcine Reproductive and Respiratory Syndrome Virus Strain BB0907 Impairs the Function of Monocyte-Derived Dendritic Cells via the Release of Soluble CD83.

Authors: Xi Chen; Juan Bai; Xuewei Liu; Zhongbao Song; Qiaoya Zhang; Xianwei Wang; Ping Jiang
Journal: J Virol Date: 2018-07-17 Impact factor: 5.103

4. The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein.

Authors: Mauricio Torres; Danilo B Medinas; José Manuel Matamala; Ute Woehlbier; Víctor Hugo Cornejo; Tatiana Solda; Catherine Andreu; Pablo Rozas; Soledad Matus; Natalia Muñoz; Carmen Vergara; Luis Cartier; Claudio Soto; Maurizio Molinari; Claudio Hetz
Journal: J Biol Chem Date: 2015-07-13 Impact factor: 5.157

ERp57, a multifunctional endoplasmic reticulum resident oxidoreductase.

1. ERp57 as a novel cellular factor controlling prion protein biosynthesis: Therapeutic potential of protein disulfide isomerases.

2. Proteomic identification of carbonylated proteins in the kidney of trichloroethene-exposed MRL+/+ mice.

3. Nsp1α of Porcine Reproductive and Respiratory Syndrome Virus Strain BB0907 Impairs the Function of Monocyte-Derived Dendritic Cells via the Release of Soluble CD83.

4. The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein.

Review 5. Regulatory functions of innate-like B cells.

6. Modulation of STIM1 and capacitative Ca2+ entry by the endoplasmic reticulum luminal oxidoreductase ERp57.

7. The disulfide isomerase ERp57 mediates platelet aggregation, hemostasis, and thrombosis.

8. Structural Analysis of Calreticulin, an Endoplasmic Reticulum-Resident Molecular Chaperone.

9. Serendipitous discovery of a novel protein signaling mechanism in heart failure.

Review 10. Inflammatory and oxidative stress in rotavirus infection.