| Literature DB >> 20079638 |
David Burdick1, Russell DeOrazio, Peter Guzzo, Alicia Habershaw, Mark Helle, Bernard Paul, Mark Wolf.
Abstract
A novel series of Delta9-tetrahydrocannabinol (Delta9-THC) analogues were synthesized to determine their potential as cannabinoid receptor modulators. Chemistry focused on conversion of the phenol of Delta9-THC to other functionality through palladium catalyzed reactions with an intermediate triflate 2. Two analogues with sub 100 nM affinity for the CB1 and CB2 receptors were identified. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20079638 DOI： 10.1016/j.bmcl.2009.12.092
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823