Literature DB >> 20079353

PTEN/mTOR and axon regeneration.

Kevin K Park1, Kai Liu, Yang Hu, Jennifer L Kanter, Zhigang He.   

Abstract

How axon regeneration is controlled in both PNS and CNS remains elusive. Mechanistic studies of axon growth during development and axon regeneration after injury reveal the PTEN dependent molecular mechanism as a commonality. This pathway could impact the processes occurring in the neuronal soma, such as mTOR-regulated protein translation, and in the axons, such as cytoskeleton assembly. In this review, we will discuss the current understanding of the involvement of these processes in the regulation of axon growth and the potential implication in promoting axon regeneration after injury. Copyright 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20079353     DOI： 10.1016/j.expneurol.2009.12.032

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


  127 in total

1.  The Synergic Effect of Tetramethylpyrazine Phosphate and Borneol for Protecting Against Ischemia Injury in Cortex and Hippocampus Regions by Modulating Apoptosis and Autophagy.

Authors:  Bin Yu; Ming Ruan; Tao Liang; Shi-Wen Huang; Yun Yu; Hai-Bo Cheng; Xiang-Chun Shen
Journal:  J Mol Neurosci       Date:  2017-08-04       Impact factor: 3.444

2.  Latanoprost promotes neurite outgrowth in differentiated RGC-5 cells via the PI3K-Akt-mTOR signaling pathway.

Authors:  Jun Zheng; Xuemei Feng; Lina Hou; Yongyao Cui; Liang Zhu; Jian Ma; Zheng Xia; Wei Zhou; Hongzhuan Chen
Journal:  Cell Mol Neurobiol       Date:  2011-01-29       Impact factor: 5.046

Review 3.  Assembly of a new growth cone after axotomy: the precursor to axon regeneration.

Authors:  Frank Bradke; James W Fawcett; Micha E Spira
Journal:  Nat Rev Neurosci       Date:  2012-02-15       Impact factor: 34.870

4.  Effect of laminin-binding BDNF on induction of recurrent laryngeal nerve regeneration by miR-222 activation of mTOR signal pathway.

Authors:  Jin Xie; Bin Jin; Da-Wei Li; Bin Shen; Ning Gong; Tian-Zhen Zhang; Pin Dong
Journal:  Am J Transl Res       Date:  2015-06-15       Impact factor: 4.060

5.  Upregulating Lin28a Promotes Axon Regeneration in Adult Mice with Optic Nerve and Spinal Cord Injury.

Authors:  Fatima M Nathan; Yosuke Ohtake; Shuo Wang; Xinpei Jiang; Armin Sami; Hua Guo; Feng-Quan Zhou; Shuxin Li
Journal:  Mol Ther       Date:  2020-04-15       Impact factor: 11.454

6.  AAV transduction of dopamine neurons with constitutively active Rheb protects from neurodegeneration and mediates axon regrowth.

Authors:  Sang Ryong Kim; Tatyana Kareva; Olga Yarygina; Nikolai Kholodilov; Robert E Burke
Journal:  Mol Ther       Date:  2011-10-18       Impact factor: 11.454

7.  An update on spinal cord injury research.

Authors:  Yimin Zou
Journal:  Neurosci Bull       Date:  2013-08       Impact factor: 5.203

8.  Tetramethylpyrazine phosphate and borneol combination therapy synergistically attenuated ischemia-reperfusion injury of the hypothalamus and striatum via regulation of apoptosis and autophagy in a rat model.

Authors:  Bin Yu; Ming Ruan; Tao Liang; Shi-Wen Huang; Sheng-Jin Liu; Hai-Bo Cheng; Xiang-Chun Shen
Journal:  Am J Transl Res       Date:  2017-11-15       Impact factor: 4.060

Review 9.  Exercise and Peripheral Nerve Grafts as a Strategy To Promote Regeneration after Acute or Chronic Spinal Cord Injury.

Authors:  Catherine C Theisen; Rahul Sachdeva; Scarlett Austin; Danielle Kulich; Victoria Kranz; John D Houle
Journal:  J Neurotrauma       Date:  2017-04-26       Impact factor: 5.269

10.  Scaffolds and stem cells: delivery of cell transplants for retinal degenerations.

Authors:  Karl E Kador; Jeffrey L Goldberg
Journal:  Expert Rev Ophthalmol       Date:  2012-10-01
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