| Literature DB >> 20077308 |
Feras Q Alali1, Ahmad A Gharaibeh, Abdullah Ghawanmeh, Khaled Tawaha, Amjad Qandil, Jason P Burgess, Arlene Sy, Yuka Nakanishi, David J Kroll, Nicholas H Oberlies.
Abstract
A new colchicinoid from Colchicum crocifolium Boiss. (Colchicaceae) was isolated and identified as N,N-dimethyl-N-deacetyl-(-)-cornigerine (5), along with four known compounds, but new to the species: (-)-colchicine (1), (-)-demecolcine (2), (-)-N-methyl-(-)-demecolcine (3) and 3-demethyl-N-methyl-(-)-demecolcine (4). All isolated compounds showed potent cytotoxicity against a human cancer cell panel.Entities:
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Year: 2010 PMID： 20077308 DOI： 10.1080/14786410902941097
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861