Literature DB >> 20075988

Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing.

Coert Margadant1, Arnoud Sonnenberg.   

Abstract

Accumulating evidence indicates that there is extensive crosstalk between integrins and TGF-beta signalling. TGF-beta affects integrin-mediated cell adhesion and migration by regulating the expression of integrins, their ligands and integrin-associated proteins. Conversely, several integrins directly control TGF-beta activation. In addition, a number of integrins can interfere with both Smad-dependent and Smad-independent TGF-beta signalling in different ways, including the regulation of the expression of TGF-beta signalling pathway components, the physical association of integrins with TGF-beta receptors and the modulation of downstream effectors. Reciprocal TGF-beta-integrin signalling is implicated in normal physiology, as well as in a variety of pathological processes including systemic sclerosis, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease and cancer; thus, integrins could provide attractive therapeutic targets to interfere with TGF-beta signalling in these processes.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20075988      PMCID： PMC2828749          DOI： 10.1038/embor.2009.276

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  77 in total

1.  Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes.

Authors:  John M Lamar; Vandana Iyer; C Michael DiPersio
Journal:  J Invest Dermatol       Date:  2007-08-30       Impact factor: 8.551

2.  alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation.

Authors:  Daniel Marsh; Sarah Dickinson; Graham W Neill; John F Marshall; Ian R Hart; Gareth J Thomas
Journal:  Cancer Res       Date:  2008-05-01       Impact factor: 12.701

3.  Role of alphavbeta6 integrin in acute biliary fibrosis.

Authors:  Bruce Wang; Brian M Dolinski; Noriko Kikuchi; Diane R Leone; Marion G Peters; Paul H Weinreb; Shelia M Violette; D Montgomery Bissell
Journal:  Hepatology       Date:  2007-11       Impact factor: 17.425

4.  MAP-kinase activity necessary for TGFbeta1-stimulated mesangial cell type I collagen expression requires adhesion-dependent phosphorylation of FAK tyrosine 397.

Authors:  Tomoko Hayashida; Ming-Hua Wu; Amy Pierce; Anne-Christine Poncelet; John Varga; H William Schnaper
Journal:  J Cell Sci       Date:  2007-12-01       Impact factor: 5.285

5.  Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.

Authors:  Gerald S Horan; Susan Wood; Victor Ona; Dan Jun Li; Matvey E Lukashev; Paul H Weinreb; Kenneth J Simon; Kyungmin Hahm; Normand E Allaire; Nicola J Rinaldi; Jaya Goyal; Carol A Feghali-Bostwick; Eric L Matteson; Carl O'Hara; Robert Lafyatis; Gerald S Davis; Xiaozhu Huang; Dean Sheppard; Shelia M Violette
Journal:  Am J Respir Crit Care Med       Date:  2007-10-04       Impact factor: 21.405

6.  Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis.

Authors:  Khalid Puthawala; Nicos Hadjiangelis; Steven C Jacoby; Emmanuel Bayongan; Zhicheng Zhao; Zhiwei Yang; Mary Louise Devitt; Gerald S Horan; Paul H Weinreb; Matvey E Lukashev; Shelia M Violette; Kristen S Grant; Cristina Colarossi; Silvia C Formenti; John S Munger
Journal:  Am J Respir Crit Care Med       Date:  2007-10-04       Impact factor: 21.405

7.  Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients.

Authors:  Jun Araya; Stephanie Cambier; Jennifer A Markovics; Paul Wolters; David Jablons; Arthur Hill; Walter Finkbeiner; Kirk Jones; V Courtney Broaddus; Dean Sheppard; Andrea Barzcak; Yuanyuan Xiao; David J Erle; Stephen L Nishimura
Journal:  J Clin Invest       Date:  2007-11       Impact factor: 14.808

8.  Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism.

Authors:  Louise A Koopman Van Aarsen; Diane R Leone; Steffan Ho; Brian M Dolinski; Patricia E McCoon; Doreen J LePage; Rebecca Kelly; Glenna Heaney; Paul Rayhorn; Carl Reid; Kenneth J Simon; Gerald S Horan; Nianjun Tao; Humphrey A Gardner; Marilyn M Skelly; Allen M Gown; Gareth J Thomas; Paul H Weinreb; Stephen E Fawell; Shelia M Violette
Journal:  Cancer Res       Date:  2008-01-15       Impact factor: 12.701

9.  alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in mice.

Authors:  Louise E Reynolds; Francesco J Conti; Rita Silva; Stephen D Robinson; Vandana Iyer; Rob Rudling; Barbara Cross; Emma Nye; Ian R Hart; C Michael Dipersio; Kairbaan M Hodivala-Dilke
Journal:  J Clin Invest       Date:  2008-03       Impact factor: 14.808

10.  Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix.

Authors:  Pierre-Jean Wipff; Daniel B Rifkin; Jean-Jacques Meister; Boris Hinz
Journal:  J Cell Biol       Date:  2007-12-17       Impact factor: 10.539
View more
  216 in total

Review 1.  Rosacea: The cytokine and chemokine network.

Authors:  Peter Arne Gerber; Bettina Alexandra Buhren; Martin Steinhoff; Bernhard Homey
Journal:  J Investig Dermatol Symp Proc       Date:  2011-12

Review 2.  Forcing stem cells to behave: a biophysical perspective of the cellular microenvironment.

Authors:  Yubing Sun; Christopher S Chen; Jianping Fu
Journal:  Annu Rev Biophys       Date:  2012-02-23       Impact factor: 12.981

Review 3.  Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities.

Authors:  Swati Bhattacharyya; Jun Wei; John Varga
Journal:  Nat Rev Rheumatol       Date:  2011-10-25       Impact factor: 20.543

Review 4.  Cellular and molecular mechanisms of renal fibrosis.

Authors:  Youhua Liu
Journal:  Nat Rev Nephrol       Date:  2011-10-18       Impact factor: 28.314

5.  Guiding epithelial cell phenotypes with engineered integrin-specific recombinant fibronectin fragments.

Authors:  Ashley C Brown; Jessica A Rowe; Thomas H Barker
Journal:  Tissue Eng Part A       Date:  2010-12-12       Impact factor: 3.845

6.  A polymorphism in the integrin αV subunit gene affects the progression of primary biliary cirrhosis in Japanese patients.

Authors:  Tatsuo Inamine; Minoru Nakamura; Ayumi Kawauchi; Yayoi Shirakawa; Hisae Hashiguchi; Yoshihiro Aiba; Akinobu Taketomi; Ken Shirabe; Makoto Nakamuta; Shigeki Hayashi; Takeo Saoshiro; Atsumasa Komori; Hiroshi Yatsuhashi; Shinji Kondo; Katsuhisa Omagari; Yoshihiko Maehara; Hiromi Ishibashi; Kazuhiro Tsukamoto
Journal:  J Gastroenterol       Date:  2010-12-01       Impact factor: 7.527

7.  Adeno-associated virus-2-mediated TGF-β1 microRNA transfection inhibits adhesion formation after digital flexor tendon injury.

Authors:  Y F Wu; W F Mao; Y L Zhou; X T Wang; P Y Liu; J B Tang
Journal:  Gene Ther       Date:  2015-10-08       Impact factor: 5.250

8.  Polydopamine-assisted BMP-2 immobilization on titanium surface enhances the osteogenic potential of periodontal ligament stem cells via integrin-mediated cell-matrix adhesion.

Authors:  Jeong Seok Lee; Jeong-Chae Lee; Jung Sun Heo
Journal:  J Cell Commun Signal       Date:  2018-05-03       Impact factor: 5.782

Review 9.  The wound healing, chronic fibrosis, and cancer progression triad.

Authors:  Brad Rybinski; Janusz Franco-Barraza; Edna Cukierman
Journal:  Physiol Genomics       Date:  2014-02-11       Impact factor: 3.107

10.  Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA methylation aberrancies.

Authors:  Nezam Altorok; Pei-Suen Tsou; Patrick Coit; Dinesh Khanna; Amr H Sawalha
Journal:  Ann Rheum Dis       Date:  2014-05-08       Impact factor: 19.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.