Literature DB >> 2007560

Genetic and molecular analyses of the SUP201 gene: a tRNA(3Arg) nonsense suppressor of yeast cyrl-2.

T Morishita1, I Uno.   

Abstract

The temperature-sensitive cyr1-2 mutant in Saccharomyces cerevisiae produces low levels of adenylate cyclase and cyclic AMP at 25 degrees C and is unable to synthesize repressible acid phosphatase at 25 degrees C. Suppressor mutants of cyr1-2 were isolated by detecting acid phosphatase activity. One of the dominant suppressor mutations isolated was designated SUP201 and characterized. The SUP201 mutant gene was isolated from a gene library made from cyr1-2 SUP201 mutant DNA. Nucleotide sequence analysis of the cloned SUP201 gene revealed that the SUP201 gene was a mutated tRNA gene flanking GCN4, which worked as a UGA suppressor.

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Year:  1991        PMID： 2007560      PMCID： PMC207795          DOI： 10.1128/jb.173.7.2406-2408.1991

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  17 in total

1.  Identification of the structural gene and nonsense alleles for adenylate cyclase in Saccharomyces cerevisiae.

Authors:  K Matsumoto; I Uno; T Ishikawa
Journal:  J Bacteriol       Date:  1984-01       Impact factor: 3.490

2.  5' untranslated sequences are required for the translational control of a yeast regulatory gene.

Authors:  G Thireos; M D Penn; H Greer
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

3.  Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase.

Authors:  T Toda; S Cameron; P Sass; M Zoller; M Wigler
Journal:  Cell       Date:  1987-07-17       Impact factor: 41.582

4.  Dimeric tRNA precursors in yeast.

Authors:  O Schmidt; J Mao; R Ogden; J Beckmann; H Sakano; J Abelson; D Söll
Journal:  Nature       Date:  1980-10-23       Impact factor: 49.962

5.  Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase.

Authors:  K Matsumoto; I Uno; Y Oshima; T Ishikawa
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

6.  Regulation of repressible acid phosphatase by cyclic AMP in Saccharomyces cerevisiae.

Authors:  K Matsumoto; I Uno; T Ishikawa
Journal:  Genetics       Date:  1984-09       Impact factor: 4.562

7.  Calcium-sensitive cls4 mutant of Saccharomyces cerevisiae with a defect in bud formation.

Authors:  Y Ohya; S Miyamoto; Y Ohsumi; Y Anraku
Journal:  J Bacteriol       Date:  1986-01       Impact factor: 3.490

8.  DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase.

Authors:  T Kataoka; D Broek; M Wigler
Journal:  Cell       Date:  1985-12       Impact factor: 41.582

9.  Positive regulation in the general amino acid control of Saccharomyces cerevisiae.

Authors:  A G Hinnebusch; G R Fink
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

10.  Control of cell division in Saccharomyces cerevisiae mutants defective in adenylate cyclase and cAMP-dependent protein kinase.

Authors:  K Matsumoto; I Uno; T Ishikawa
Journal:  Exp Cell Res       Date:  1983-06       Impact factor: 3.905
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  3 in total

1.  Characterization of the cyr1-2 UGA mutation in Saccharomyces cerevisiae.

Authors:  T Morishita; A Matsuura; I Uno
Journal:  Mol Gen Genet       Date:  1993-03

2.  Characterization of the MKS1 gene, a new negative regulator of the Ras-cyclic AMP pathway in Saccharomyces cerevisiae.

Authors:  A Matsuura; Y Anraku
Journal:  Mol Gen Genet       Date:  1993-04

3.  A rare tRNA-Arg(CCU) that regulates Ty1 element ribosomal frameshifting is essential for Ty1 retrotransposition in Saccharomyces cerevisiae.

Authors:  K Kawakami; S Pande; B Faiola; D P Moore; J D Boeke; P J Farabaugh; J N Strathern; Y Nakamura; D J Garfinkel
Journal:  Genetics       Date:  1993-10       Impact factor: 4.562
  3 in total

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