BACKGROUND AND PURPOSE: We investigated whether neuroglobin, a neuronal protein that protects neurons from hypoxic-ischemic injury, is upregulated in ischemic stroke. METHODS: Neuroglobin immunoreactivity was measured in brain tissue from control subjects and patients with ischemic stroke. RESULTS: Neuroglobin was detected in several brain areas, and its expression was increased in the cortical peri-infarct region after stroke. CONCLUSIONS: Ischemic stroke increases expression of the neuroprotective protein neuroglobin, suggesting neuroglobin may represent a novel target for stroke therapy.
BACKGROUND AND PURPOSE: We investigated whether neuroglobin, a neuronal protein that protects neurons from hypoxic-ischemic injury, is upregulated in ischemic stroke. METHODS:Neuroglobin immunoreactivity was measured in brain tissue from control subjects and patients with ischemic stroke. RESULTS:Neuroglobin was detected in several brain areas, and its expression was increased in the cortical peri-infarct region after stroke. CONCLUSIONS:Ischemic stroke increases expression of the neuroprotective protein neuroglobin, suggesting neuroglobin may represent a novel target for stroke therapy.
Authors: Adil A Khan; Yaoming Wang; Yunjuan Sun; Xiao Ou Mao; Lin Xie; Erin Miles; Justin Graboski; Sylvia Chen; Lisa M Ellerby; Kunlin Jin; David A Greenberg Journal: Proc Natl Acad Sci U S A Date: 2006-11-10 Impact factor: 11.205
Authors: Adil A Khan; Xiao Ou Mao; Surita Banwait; Kunlin Jin; David A Greenberg Journal: Proc Natl Acad Sci U S A Date: 2007-11-19 Impact factor: 11.205
Authors: Adil A Khan; Xiao Ou Mao; Surita Banwait; Celine M DerMardirossian; Gary M Bokoch; Kunlin Jin; David A Greenberg Journal: FASEB J Date: 2008-01-15 Impact factor: 5.191
Authors: Anita S Y Chan; Sindhu Saraswathy; Matus Rehak; Mari Ueki; Narsing A Rao Journal: Invest Ophthalmol Vis Sci Date: 2012-02-13 Impact factor: 4.799
Authors: Oscar Hidalgo-Lanussa; Marco Ávila-Rodriguez; Eliana Baez-Jurado; Jairo Zamudio; Valentina Echeverria; Luis Miguel Garcia-Segura; George E Barreto Journal: Mol Neurobiol Date: 2017-09-25 Impact factor: 5.590
Authors: Thottala Jayaraman; Jesús Tejero; Bill B Chen; Arlin B Blood; Sheila Frizzell; Calli Shapiro; Mauro Tiso; Brian L Hood; Xunde Wang; Xuejun Zhao; Thomas P Conrads; Rama K Mallampalli; Mark T Gladwin Journal: J Biol Chem Date: 2011-09-29 Impact factor: 5.157