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Literature DB >> 20074911

Orbital frontal cortex in treatment-naïve pediatric obsessive-compulsive disorder.

Frank Macmaster¹, Anvi Vora, Phillip Easter, Carrie Rix, David Rosenberg.

Abstract

The orbital frontal cortex (OFC) has been implicated in obsessive-compulsive disorder (OCD). Participants comprised 28 treatment-naïve pediatric OCD patients and 21 controls, who were examined using magnetic resonance imaging. OCD patients had larger right but not left OFC white matter volume than controls. This is fresh evidence implicating white matter in OCD. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Year: 2010 PMID： 20074911 PMCID： PMC2830852 DOI： 10.1016/j.pscychresns.2009.08.005

Source DB: PubMed Journal: Psychiatry Res ISSN： 0165-1781 Impact factor: 3.222

31 in total

1. 'Compulsive' lever pressing in rats is enhanced following lesions to the orbital cortex, but not to the basolateral nucleus of the amygdala or to the dorsal medial prefrontal cortex.

Authors: Daphna Joel; Julia Doljansky; Daniela Schiller
Journal: Eur J Neurosci Date: 2005-04 Impact factor: 3.386

2. Decrease in thalamic volumes of pediatric patients with obsessive-compulsive disorder who are taking paroxetine.

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Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2006-07-20 Impact factor: 5.067

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Journal: Neuropsychopharmacology Date: 1989-03 Impact factor: 7.853

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Journal: Arch Gen Psychiatry Date: 1994-01

8. Increased medial thalamic choline found in pediatric patients with obsessive-compulsive disorder versus major depression or healthy control subjects: a magnetic resonance spectroscopy study.

Authors: Ethan A Smith; Aileen Russell; Elisa Lorch; S Preeya Banerjee; Michelle Rose; Jennifer Ivey; Rashmi Bhandari; Gregory J Moore; David R Rosenberg
Journal: Biol Psychiatry Date: 2003-12-15 Impact factor: 13.382

Orbital frontal cortex in treatment-naïve pediatric obsessive-compulsive disorder.

1. 'Compulsive' lever pressing in rats is enhanced following lesions to the orbital cortex, but not to the basolateral nucleus of the amygdala or to the dorsal medial prefrontal cortex.

2. Decrease in thalamic volumes of pediatric patients with obsessive-compulsive disorder who are taking paroxetine.

3. Development of a rating scale for primary depressive illness.

4. Volumetric MRI study of key brain regions implicated in obsessive-compulsive disorder.

5. Cerebral glucose metabolic rates in obsessive compulsive disorder.

Review 6. PET imaging in obsessive compulsive disorder with and without depression.

7. Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography.

8. Increased medial thalamic choline found in pediatric patients with obsessive-compulsive disorder versus major depression or healthy control subjects: a magnetic resonance spectroscopy study.

9. Developmental differences in white matter architecture between boys and girls.

10. A meta-analysis of functional neuroimaging in obsessive-compulsive disorder.

1. Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: a preliminary study.

2. Do defense styles of ego relate to volumes of orbito-frontal cortex in patients with obsessive-compulsive disorder?

Review 3. A review of obsessive-compulsive disorder in children and adolescents.