Literature DB >> 20074282

Actobiotics as a novel method for cytokine delivery.

Lothar Steidler1, Pieter Rottiers, Bernard Coulie.   

Abstract

Interleukin-10 (IL-10) is central in immune downregulation, but so far its use in inflammatory diseases remains cumbersome. For treatment of inflammatory bowel disease, adequate amounts of IL-10 must reach the intestinal lining. Systemic injection of a pharmacologically active doses of recombinant human (rh) IL-10 results in very low mucosal levels of protein and severe toxicity and side effects. In animal models, topical and active delivery of IL-10 by ingestion of recombinant Lactococcus lactis (L. lactis) was shown to be a valuable alternative. Starting thereof we have developed a novel pharmaceutical platform. Our expertise and TopAct (topical and active) delivery technology allows use of recombinant L. lactis- ActoBiotics- in clinical practice. Here we discuss the development of recombinant L. lactis for intestinal delivery of rhIL-10 in humans.

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Year:  2009        PMID： 20074282     DOI： 10.1111/j.1749-6632.2009.05067.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  15 in total

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Review 10.  Role of commensal and probiotic bacteria in human health: a focus on inflammatory bowel disease.

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Journal:  Microb Cell Fact       Date:  2013-07-23       Impact factor: 5.328
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