| Literature DB >> 20072841 |
R Wäsch1, J Hasskarl, D Schnerch, M Lübbert.
Abstract
Human Polo-like kinase 1 (Plk1) is an essential regulator of mitotic progression. Targeted inhibition of this kinase was effective in killing tumor cells in vitro and in vivo. The Plk1 inhibitor BI_2536 was well tolerated and showed antitumor activity in the first clinical trials enrolling patients with advanced solid tumors and refractory or relapsed acute myeloid leukemia.Entities:
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Year: 2010 PMID： 20072841 DOI： 10.1007/978-3-642-01222-8_15
Source DB: PubMed Journal: Recent Results Cancer Res ISSN： 0080-0015