OBJECTIVE: To investigate the effect of a 36-ingredient micronutrient formula consisting mainly of minerals and vitamins in the treatment of adults with both ADHD and severe mood dysregulation (SMD). METHOD: 14 medication-free adults (9 men, 5 women; 18-55 years) with ADHD and SMD completed an 8-week open-label trial. RESULTS: A minority reported transitory mild side effects. Significant improvements were noted across informants (self, observer, clinician) on measures of inattention and hyperactivity/impulsivity, mood, quality of life, anxiety, and stress all with medium to very large effect sizes (all ps < .01); however, the mean of inattention remained in a clinical range whereas the means on measures of mood and hyperactivity/impulsivity were normalized. Follow-up data showed maintenance of changes or further improvement for those who stayed on the micronutrients. CONCLUSIONS: Although this study, as an open trial, does not in itself prove efficacy, it provides preliminary evidence supporting the need for a randomized clinical trial of micronutrients as treatment for the more complex presentations of ADHD.
RCT Entities:
OBJECTIVE: To investigate the effect of a 36-ingredient micronutrient formula consisting mainly of minerals and vitamins in the treatment of adults with both ADHD and severe mood dysregulation (SMD). METHOD: 14 medication-free adults (9 men, 5 women; 18-55 years) with ADHD and SMD completed an 8-week open-label trial. RESULTS: A minority reported transitory mild side effects. Significant improvements were noted across informants (self, observer, clinician) on measures of inattention and hyperactivity/impulsivity, mood, quality of life, anxiety, and stress all with medium to very large effect sizes (all ps < .01); however, the mean of inattention remained in a clinical range whereas the means on measures of mood and hyperactivity/impulsivity were normalized. Follow-up data showed maintenance of changes or further improvement for those who stayed on the micronutrients. CONCLUSIONS: Although this study, as an open trial, does not in itself prove efficacy, it provides preliminary evidence supporting the need for a randomized clinical trial of micronutrients as treatment for the more complex presentations of ADHD.
Authors: Elisabeth A Frazier; Barbara Gracious; L Eugene Arnold; Mark Failla; Chureeporn Chitchumroonchokchai; Diane Habash; Mary A Fristad Journal: J Child Adolesc Psychopharmacol Date: 2013-10 Impact factor: 2.576
Authors: J Steven A Simpson; Susan G Crawford; Estelle T Goldstein; Catherine Field; Ellen Burgess; Bonnie J Kaplan Journal: BMC Psychiatry Date: 2011-04-18 Impact factor: 3.630
Authors: Jeanette M Johnstone; Irene Hatsu; Gabriella Tost; Priya Srikanth; Leanna P Eiterman; Alisha M Bruton; Hayleigh K Ast; Lisa M Robinette; Madeline M Stern; Elizabeth G Millington; Barbara L Gracious; Andrew J Hughes; Brenda M Y Leung; L Eugene Arnold Journal: J Am Acad Child Adolesc Psychiatry Date: 2021-07-22 Impact factor: 13.113