Literature DB >> 20070173

Inhalability of micron particles through the nose and mouth.

Camby Mei King Se1, Kiao Inthavong, Jiyuan Tu.   

Abstract

Aspiration efficiencies from nose and mouth inhalations are investigated at low and high inhalation rates by using the commercial Computational Fluid Dynamics (CFD) software CFX 11. A realistic human head with detailed facial features was constructed. Facial features were matched to represent the 50th percentile of a human male, aged between 20 and 65 years old, based on anthropometric data. The constant freestream velocity was 0.2 ms(-1), normal to the face, and inhalation rates through the mouth and nose were 15 liters per minute (LPM) for light breathing and 40 LPM for heavy breathing. It was found that the flow field in the near breathing region exhibited vertical direction caused by the presence of the torso where the airstream diverges as it flows around and over the body. The critical area concept was used as a tool to determine the aspiration efficiency of particles. Comparisons between critical areas for the nose and mouth inhalations show similar geometric properties such as the area's shape, and its vertical distance location on the x-z plane located at y = 80 cm upstream. The critical area sizes were found to be slightly larger for the mouth inhalation mainly due to the larger mouth area and also the aligned orientation of the mouth to the upstream flow, whereas the nose is perpendicular to the upstream flow. This study was undertaken to establish the flow field in the near breathing region that will help to characterize the flow and particle field for initial boundary conditions leading to a more holistic modeling approach of respiration through the internal nasal cavity and mouth.

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Year:  2010        PMID: 20070173     DOI: 10.3109/08958370903295204

Source DB:  PubMed          Journal:  Inhal Toxicol        ISSN: 0895-8378            Impact factor:   2.724


  10 in total

1.  Diet and environment 1.2 million years ago revealed through analysis of dental calculus from Europe's oldest hominin at Sima del Elefante, Spain.

Authors:  Karen Hardy; Anita Radini; Stephen Buckley; Ruth Blasco; Les Copeland; Francesc Burjachs; Josep Girbal; Riker Yll; Eudald Carbonell; Jose María Bermúdez de Castro
Journal:  Naturwissenschaften       Date:  2016-12-15

2.  Computational fluid dynamics investigation of human aspiration in low-velocity air: orientation effects on mouth-breathing simulations.

Authors:  T Renée Anthony; Kimberly R Anderson
Journal:  Ann Occup Hyg       Date:  2013-01-12

3.  Computational fluid dynamics investigation of human aspiration in low velocity air: orientation effects on nose-breathing simulations.

Authors:  Kimberly R Anderson; T Renée Anthony
Journal:  Ann Occup Hyg       Date:  2014-03-24

4.  An empirical model of human aspiration in low-velocity air using CFD investigations.

Authors:  T Renée Anthony; Kimberly R Anderson
Journal:  J Occup Environ Hyg       Date:  2015       Impact factor: 2.155

5.  Uncertainty in aspiration efficiency estimates from torso simplifications in computational fluid dynamics simulations.

Authors:  Kimberly R Anderson; T Renée Anthony
Journal:  Ann Occup Hyg       Date:  2012-09-24

6.  Influence of secondary aspiration on human aspiration efficiency.

Authors:  K R Anderson; T Renee Anthony
Journal:  J Aerosol Sci       Date:  2014-09       Impact factor: 3.433

7.  Correlation of regional deposition dosage for inhaled nanoparticles in human and rat olfactory.

Authors:  Lin Tian; Yidan Shang; Rui Chen; Ru Bai; Chunying Chen; Kiao Inthavong; Jiyuan Tu
Journal:  Part Fibre Toxicol       Date:  2019-01-25       Impact factor: 9.400

8.  A combined experimental and numerical study on upper airway dosimetry of inhaled nanoparticles from an electrical discharge machine shop.

Authors:  Lin Tian; Yidan Shang; Rui Chen; Ru Bai; Chunying Chen; Kiao Inthavong; Jiyuan Tu
Journal:  Part Fibre Toxicol       Date:  2017-07-12       Impact factor: 9.400

9.  Regional deposition of the allergens and micro-aerosols in the healthy human nasal airways.

Authors:  Mohammad Hazeri; Mohammad Faramarzi; Sasan Sadrizadeh; Goodarz Ahmadi; Omid Abouali
Journal:  J Aerosol Sci       Date:  2020-10-19       Impact factor: 3.433

10.  New Approach Methodology for Assessing Inhalation Risks of a Contact Respiratory Cytotoxicant: Computational Fluid Dynamics-Based Aerosol Dosimetry Modeling for Cross-Species and In Vitro Comparisons.

Authors:  Richard A Corley; Andrew P Kuprat; Sarah R Suffield; Senthil Kabilan; Paul M Hinderliter; Kevin Yugulis; Tharacad S Ramanarayanan
Journal:  Toxicol Sci       Date:  2021-08-03       Impact factor: 4.849

  10 in total

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