Literature DB >> 20070074

Mass spectrometric evidence for the existence of distinct modifications of different proteins by 2(E),4(E)-decadienal.

Xiaochun Zhu1, Xiaoxia Tang, Jianye Zhang, Gregory P Tochtrop, Vernon E Anderson, Lawrence M Sayre.   

Abstract

2(E),4(E)-Decadienal (DDE), a lipid peroxidation product, was found to covalently modify Lys residues of different proteins by different reactions using mass spectrometry (MALDI-TOF-MS and LC-ESI-MS). DDE mainly formed Lys Schiff base adducts with cytochrome c and ribonuclease A at 10 min, but these reversibly formed adducts almost disappeared after 24 h. In contrast, beta-lactoglobulin (beta-LG) was highly modified by DDE after 24 h. In addition to the Lys Schiff base adducts, DDE formed novel Lys pyridinium adducts as well as Cys Michael adducts with beta-LG.

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Year:  2010        PMID： 20070074      PMCID： PMC2838956          DOI： 10.1021/tx900379a

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN： 0893-228X            Impact factor:   3.739


  32 in total

1.  Aldehydic lipid peroxidation products derived from linoleic acid.

Authors:  P Spiteller; W Kern; J Reiner; G Spiteller
Journal:  Biochim Biophys Acta       Date:  2001-04-30

2.  Modification of horse heart cytochrome c with trans-2-hexenal.

Authors:  L Zídek; P Dolezel; J Chmelík; A G Baker; M Novotny
Journal:  Chem Res Toxicol       Date:  1997-06       Impact factor: 3.739

3.  Formation of a dihydropyridine derivative as a potential cross-link derived from malondialdehyde in physiological systems.

Authors:  D A Slatter; M Murray; A J Bailey
Journal:  FEBS Lett       Date:  1998-01-16       Impact factor: 4.124

4.  Structural characterization of a 4-hydroxy-2-alkenal-derived fluorophore that contributes to lipoperoxidation-dependent protein cross-linking in aging and degenerative disease.

Authors:  G Xu; L M Sayre
Journal:  Chem Res Toxicol       Date:  1998-04       Impact factor: 3.739

5.  The alpha, beta, gamma, delta-unsaturated aldehyde 2-trans-4-trans-decadienal disturbs DNA replication and mitotic events in early sea urchin embryos.

Authors:  Espen Hansen; Yasmine Even; Anne-Marie Genevière
Journal:  Toxicol Sci       Date:  2004-06-16       Impact factor: 4.849

6.  Structural definition of early lysine and histidine adduction chemistry of 4-hydroxynonenal.

Authors:  D V Nadkarni; L M Sayre
Journal:  Chem Res Toxicol       Date:  1995-03       Impact factor: 3.739

7.  Inactivation of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Selective modification of an active-site lysine.

Authors:  L I Szweda; K Uchida; L Tsai; E R Stadtman
Journal:  J Biol Chem       Date:  1993-02-15       Impact factor: 5.157

8.  Acrolein is a product of lipid peroxidation reaction. Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins.

Authors:  K Uchida; M Kanematsu; Y Morimitsu; T Osawa; N Noguchi; E Niki
Journal:  J Biol Chem       Date:  1998-06-26       Impact factor: 5.157

9.  Chemical characterization of a protein-4-hydroxy-2-nonenal cross-link: immunochemical detection in mitochondria exposed to oxidative stress.

Authors:  J A Cohn; L Tsai; B Friguet; L I Szweda
Journal:  Arch Biochem Biophys       Date:  1996-04-01       Impact factor: 4.013

10.  Reaction of N-acetylglycyllysine methyl ester with 2-alkenals: an alternative model for covalent modification of proteins.

Authors:  A Baker; L Zídek; D Wiesler; J Chmelík; M Pagel; M V Novotny
Journal:  Chem Res Toxicol       Date:  1998-07       Impact factor: 3.739
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  4 in total

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Journal:  Redox Biol       Date:  2019-02-07       Impact factor: 11.799

4.  A Metabolic Probe-Enabled Strategy Reveals Uptake and Protein Targets of Polyunsaturated Aldehydes in the Diatom Phaeodactylum tricornutum.

Authors:  Stefanie Wolfram; Natalie Wielsch; Yvonne Hupfer; Bettina Mönch; Hui-Wen Lu-Walther; Rainer Heintzmann; Oliver Werz; Aleš Svatoš; Georg Pohnert
Journal:  PLoS One       Date:  2015-10-23       Impact factor: 3.240
  4 in total

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