BACKGROUND: Growing teratoma syndrome (GTS) is rare and is defined as an enlarging mature teratoma that arises during or after chemotherapy for a malignant germ cell tumor, with normalization of previously elevated serum tumor markers. CASE: A 30-year-old nulliparous Japanese woman was diagnosed as having a stage IIIa immature teratoma. After fertility-sparing surgery, she received 4 cycles of chemotherapy consisting of cisplatin, etoposide and bleomycin. Thereafter, she successfully gave birth twice. Eight years after the initial surgery, a mass mimicking an adrenal tumor was resected laparoscopically. Surgical specimens revealed a mature teratoma, and she was diagnosed as having GTS postoperatively. CONCLUSION: Clinicians should consider that GTS may present late, even after pregnancy. Therefore, long-term follow-up of patients treated for ovarian immature teratoma should be mandatory. Copyright (c) 2010 S. Karger AG, Basel.
BACKGROUND: Growing teratoma syndrome (GTS) is rare and is defined as an enlarging mature teratoma that arises during or after chemotherapy for a malignant germ cell tumor, with normalization of previously elevated serum tumor markers. CASE: A 30-year-old nulliparous Japanese woman was diagnosed as having a stage IIIa immature teratoma. After fertility-sparing surgery, she received 4 cycles of chemotherapy consisting of cisplatin, etoposide and bleomycin. Thereafter, she successfully gave birth twice. Eight years after the initial surgery, a mass mimicking an adrenal tumor was resected laparoscopically. Surgical specimens revealed a mature teratoma, and she was diagnosed as having GTS postoperatively. CONCLUSION: Clinicians should consider that GTS may present late, even after pregnancy. Therefore, long-term follow-up of patients treated for ovarian immature teratoma should be mandatory. Copyright (c) 2010 S. Karger AG, Basel.
Authors: Nirmala Kampan; Trika Irianta; Arifuddin Djuana; Lim Pei Shan; Mohd Hashim Omar; Ahmad Zailani Hatta Mohd Dali Journal: Case Rep Obstet Gynecol Date: 2012-05-08
Authors: Srdjan Saso; Nicolas Galazis; Christos Iacovou; Kleio Kappatou; Menelaos Tzafetas; Benjamin Jones; Joseph Yazbek; Konstantinos Lathouras; Jonathan Anderson; Long R Jiao; Richard J Smith Journal: Future Sci OA Date: 2019-10-10