AIM: To evaluate previously developed classification models to make implementation in primary care possible and aid early identification of persons at risk for dementia. METHODS: Data were drawn from the OCTO-Twin study. At baseline, 521 persons >or= 80 years of age were nondemented, and for 387 a blood sample was available. Predictors of dementia were collected and analyzed in initially nondemented persons using generalized estimating equations and Cox survival analyses. RESULTS: In the basic model using predictors already known or easily obtained (basic set), the mean 2-year predictive value increased from 6.9 to 28.8% in persons with memory complaints and an MMSE score <or= 25. In the extended model, using both the basic set and an extended set of predictors requiring further assessment, the 8-year predictive value increased from 15.0 to 45.8% in persons with low cholesterol and an MMSE score <or= 24. CONCLUSION: Both models can contribute to an improved early identification of persons at risk for dementia in primary care.
AIM: To evaluate previously developed classification models to make implementation in primary care possible and aid early identification of persons at risk for dementia. METHODS: Data were drawn from the OCTO-Twin study. At baseline, 521 persons >or= 80 years of age were nondemented, and for 387 a blood sample was available. Predictors of dementia were collected and analyzed in initially nondemented persons using generalized estimating equations and Cox survival analyses. RESULTS: In the basic model using predictors already known or easily obtained (basic set), the mean 2-year predictive value increased from 6.9 to 28.8% in persons with memory complaints and an MMSE score <or= 25. In the extended model, using both the basic set and an extended set of predictors requiring further assessment, the 8-year predictive value increased from 15.0 to 45.8% in persons with low cholesterol and an MMSE score <or= 24. CONCLUSION: Both models can contribute to an improved early identification of persons at risk for dementia in primary care.
Authors: M Gatz; P Svedberg; N L Pedersen; J A Mortimer; S Berg; B Johansson Journal: J Gerontol B Psychol Sci Soc Sci Date: 2001-09 Impact factor: 4.077
Authors: L Fratiglioni; L J Launer; K Andersen; M M Breteler; J R Copeland; J F Dartigues; A Lobo; J Martinez-Lage; H Soininen; A Hofman Journal: Neurology Date: 2000 Impact factor: 9.910
Authors: Alan Gevins; Aaron B Ilan; An Jiang; Cynthia S Chan; Deborah Gelinas; Michael E Smith; Linda K McEvoy; Emilie Schwager; Mayra Padilla; Zachary Davis; Kimford J Meador; James Patterson; Ruth O'Hara Journal: Dement Geriatr Cogn Disord Date: 2010-11-27 Impact factor: 2.959
Authors: Dorina Cadar; Blossom C M Stephan; Carol Jagger; Boo Johansson; Scott M Hofer; Andrea M Piccinin; Graciela Muniz-Terrera Journal: Int J Geriatr Psychiatry Date: 2015-10-15 Impact factor: 3.485