| Literature DB >> 20067796 |
Tsuyoshi Sato1, Takahiro Abe, Dai Chida, Norimichi Nakamoto, Naoko Hori, Shoichiro Kokabu, Yasuaki Sakata, Yasuhisa Tomaru, Takanori Iwata, Michihiko Usui, Katsuya Aiko, Tetsuya Yoda.
Abstract
Recent studies have indicated that acetylcholine (ACh) plays a vital role in various tissues, while the role of ACh in bone metabolism remains unclear. Here we demonstrated that ACh induced cell proliferation and reduced alkaline phosphatase (ALP) activity via nicotinic (nAChRs) and muscarinic acetylcholine receptors (mAChRs) in osteoblasts. We detected mRNA expression of several nAChRs and mAChRs. Furthermore, we showed that cholinergic components were up-regulated and subunits/subtypes of acetylcholine receptors altered during osteoblast differentiation. To our knowledge, this is the first report demonstrating that osteoblasts express specific acetylcholine receptors and cholinergic components and that ACh plays a possible role in regulating the proliferation and differentiation of osteoblasts. Crown Copyright 2010. Published by Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20067796 DOI： 10.1016/j.febslet.2010.01.001
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124