Literature DB >> 20067791

Nonsense-mediated translational repression involves exon junction complex downstream of premature translation termination codon.

Hyung Chul Lee1, Nara Oh, Hana Cho, Junho Choe, Yoon Ki Kim.   

Abstract

Human transforming growth factor-beta receptor type 2 (TGFbetaR2) mRNA harboring a premature translation termination codon (PTC) generated by frameshift mutation is targeted for nonsense-mediated translational repression (NMTR), rather than nonsense-mediated mRNA decay (NMD). Here we show that exon junction complex (EJC) downstream of a PTC plays an inhibitory role in translation of TGFbetaR2 mRNA. Translational repression by core EJC components occurs after formation of 80S ribosome complex, which is demonstrated using different types of internal ribosome entry sites (IRESes). Our findings implicate EJCs or core EJC components as negative regulators of translation. Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20067791     DOI： 10.1016/j.febslet.2010.01.003

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

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3.  The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis.

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Journal:  Hum Mol Genet       Date:  2013-03-28       Impact factor: 6.150

4.  Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay.

Authors:  Nicholas J McGlincy; Lit-Yeen Tan; Nicodeme Paul; Mihaela Zavolan; Kathryn S Lilley; Christopher W J Smith
Journal:  BMC Genomics       Date:  2010-10-14       Impact factor: 3.969

5.  Rh D blood group conversion using transcription activator-like effector nucleases.

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Review 6.  Kinases of eIF2a Switch Translation of mRNA Subset during Neuronal Plasticity.

Authors:  Ekaterina Chesnokova; Natalia Bal; Peter Kolosov
Journal:  Int J Mol Sci       Date:  2017-10-22       Impact factor: 5.923

7.  Multiple mechanisms repress N-Bak mRNA translation in the healthy and apoptotic neurons.

Authors:  M Jakobson; M Jakobson; O Llano; J Palgi; U Arumäe
Journal:  Cell Death Dis       Date:  2013-08-22       Impact factor: 8.469

Review 8.  When a ribosome encounters a premature termination codon.

Authors:  Jungwook Hwang; Yoon Ki Kim
Journal:  BMB Rep       Date:  2013-01       Impact factor: 4.778

Review 9.  Non-coding functions of alternative pre-mRNA splicing in development.

Authors:  Stefan Mockenhaupt; Eugene V Makeyev
Journal:  Semin Cell Dev Biol       Date:  2015-10-19       Impact factor: 7.727

10.  Fractionation iCLIP detects persistent SR protein binding to conserved, retained introns in chromatin, nucleoplasm and cytoplasm.

Authors:  Mattia Brugiolo; Valentina Botti; Na Liu; Michaela Müller-McNicoll; Karla M Neugebauer
Journal:  Nucleic Acids Res       Date:  2017-10-13       Impact factor: 16.971
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