| Literature DB >> 20067445 |
Deguo Wang1, Wenzhi Shen, Fengxiang Zhang, Minglong Chen, Hongwu Chen, Kejiang Cao.
Abstract
The involvement of connexins in regulating cell growth and death has recently been reported. We have investigated whether Cx43 (connexin43) contributes to MSC (mesenchymal stem cell) survival and improves therapeutic efficacy in MI (myocardial infarction). Genetically modified Cx43 MSCs were exposed to hypoxic conditions or injected intramyocardially into a rat MI model. MSCs overexpressing Cx43, with more Bcl-2 and phosphorylated Akt, but less Bax, were relatively tolerant to hypoxic injury. After transplantation, this Cx43 overexpression enhanced cell survival and reduced infarct size, improving contractile performance. Cx43 inhibition by SiRNA reversed the effects of Cx43 overexpression. Therefore, Cx43 may act as a potential target for improving the therapeutic efficacy of MSCs in ischaemic heart disease.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20067445 DOI： 10.1042/CBI20090118
Source DB: PubMed Journal: Cell Biol Int ISSN： 1065-6995 Impact factor: 3.612