OBJECTIVE: To optimize solubilizing process of Qingkailing injection. METHOD: Uniform design experimental method and GA-BPNN modeling method were applied to optimize the technical parameters, and the solubility of cholic acid in medium was taken as optimizing index. RESULT: The type of solubilizer and pH of medium had greater impact on the index than the concentration for solubilizer. The optimum solubilizer was Tween-80. In a certain range the higher pH of medium was optimum; it was not necessary to use high-concentration solubilizer although there was positive correlation between the index and the concentration of solubilizer. CONCLUSION: Uniform design combined with GA-BPNN modeling method is suitable for optimization of solubilizing process of Chinese materia medica injection, which has certain practical application value.
OBJECTIVE: To optimize solubilizing process of Qingkailing injection. METHOD: Uniform design experimental method and GA-BPNN modeling method were applied to optimize the technical parameters, and the solubility of cholic acid in medium was taken as optimizing index. RESULT: The type of solubilizer and pH of medium had greater impact on the index than the concentration for solubilizer. The optimum solubilizer was Tween-80. In a certain range the higher pH of medium was optimum; it was not necessary to use high-concentration solubilizer although there was positive correlation between the index and the concentration of solubilizer. CONCLUSION: Uniform design combined with GA-BPNN modeling method is suitable for optimization of solubilizing process of Chinese materia medica injection, which has certain practical application value.