| Literature DB >> 20066876 |
Mi Young Kim1, Julia Reyna, Li-Sha Chen, Maggie Zeichner-David.
Abstract
The transcription factor NFI-C is essential for root development. Mice lacking NFI-C develop abnormal roots and lose their teeth, resembling radicular dentin dysplasia I in humans. The purpose of this study was to understand the role of NFI-C in dentinogenesis. The authors found statistically significant increases in the expression of several mRNAs in cells lacking NFI-C, suggesting that these molecules might interfere with odontoblast cell migration and differentiation, and consequently with root development.Entities:
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Year: 2009 PMID： 20066876
Source DB: PubMed Journal: J Calif Dent Assoc ISSN： 1043-2256