Literature DB >> 20066211

Fluorescence properties and cellular distribution of the investigational anticancer drug triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex.

Christian R Kowol1, Robert Trondl, Vladimir B Arion, Michael A Jakupec, Irene Lichtscheidl, Bernhard K Keppler.   

Abstract

Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), which entered several phase I and II clinical trials as an antitumor chemotherapeutic agent, was found to possess intrinsic fluorescence properties (lambda(ex) = 360 nm), which enabled us to monitor the uptake and intracellular distribution in living human cancer cells by fluorescence microscopy.

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Year:  2009        PMID： 20066211     DOI： 10.1039/b919119b

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  10 in total

1.  Design and synthesis of novel N()-substituted thiosemicarbazones bearing a pyrrole unit as potential anticancer agents.

Authors:  Taofeng Zhu; Shanshan Shen; Qin Lu; Xingpei Ye; Weiliang Ding; Ruhua Chen; Jing Xie; Wenjiao Zhu; Jun Xu; Lei Jia; Weina Wu; Tieliang Ma
Journal:  Oncol Lett       Date:  2017-04-05       Impact factor: 2.967

2.  Cytotoxic Evaluation of 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbazone, 3-AP, in Peripheral Blood Lymphocytes of Patients with Refractory Solid Tumors using Electron Paramagnetic Resonance.

Authors:  Jill M Kolesar; Kamakshi Sachidanandam; William R Schelman; Jens Eickhoff; Kyle D Holen; Anne M Traynor; Dona B Alberti; James P Thomas; Christopher R Chitambar; George Wilding; William E Antholine
Journal:  Exp Ther Med       Date:  2011-01       Impact factor: 2.447

3.  Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study.

Authors:  Éva A Enyedy; Michael F Primik; Christian R Kowol; Vladimir B Arion; Tamás Kiss; Bernhard K Keppler
Journal:  Dalton Trans       Date:  2011-04-27       Impact factor: 4.390

4.  Thiosemicarbazone-based selective proliferation inactivators inhibit gastric cancer cell growth, invasion, and migration.

Authors:  Biao Hu; Bo Wang; Bing Zhao; Qian Guo; Zhong-Hua Li; Xin-Hui Zhang; Guang-Yao Liu; Ying Liu; Ying Tang; Fan Luo; Ya Du; Ya-Xin Chen; Li-Ying Ma; Hong-Min Liu
Journal:  Medchemcomm       Date:  2017-10-23       Impact factor: 3.597

5.  Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study.

Authors:  Ana Popović-Bijelić; Christian R Kowol; Maria E S Lind; Jinghui Luo; Fahmi Himo; Eva A Enyedy; Vladimir B Arion; Astrid Gräslund
Journal:  J Inorg Biochem       Date:  2011-07-31       Impact factor: 4.155

6.  1-[4-(Di-methyl-amino)-benzyl-idene]-4-o-tolyl-thio-semicarbazide.

Authors:  Rui-Yun Huang; Qin-Juan Xu; Li-Rong Lin
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-05-18

7.  HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy.

Authors:  Ju-Hee Lee; Kyung Hee Jung; Hyunseung Lee; Mi Kwon Son; Sun-Mi Yun; Sung-Hoon Ahn; Kyeong-Ryoon Lee; Soyoung Lee; Donghee Kim; Sungwoo Hong; Soon-Sun Hong
Journal:  Oncotarget       Date:  2014-10-30

8.  Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates.

Authors:  Bing Zhao; Xinhui Zhang; Tingting Yu; Ying Liu; Xiaoling Zhang; Yongfang Yao; Xuejian Feng; Hongmin Liu; Dequan Yu; Liying Ma; Shangshang Qin
Journal:  Acta Pharm Sin B       Date:  2020-07-16       Impact factor: 11.413

9.  Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention.

Authors:  Christian R Kowol; Walter Miklos; Sarah Pfaff; Sonja Hager; Sebastian Kallus; Karla Pelivan; Mario Kubanik; Éva A Enyedy; Walter Berger; Petra Heffeter; Bernhard K Keppler
Journal:  J Med Chem       Date:  2016-07-07       Impact factor: 7.446

Review 10.  The Role of Zinc(II) Ion in Fluorescence Tuning of Tridentate Pincers: A Review.

Authors:  Rosita Diana; Barbara Panunzi
Journal:  Molecules       Date:  2020-10-28       Impact factor: 4.411
  10 in total

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