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Literature DB >> 20066072

Discovering NF-kappaB.

Abstract

David Baltimore recalls the experiments that led to the discovery of the NF-kappaB transcription factor more than 20 years ago.

Entities: Disease

Mesh：

Substances：
NF-kappa B

Year: 2009 PMID： 20066072 PMCID： PMC2742082 DOI： 10.1101/cshperspect.a000026

Source DB: PubMed Journal: Cold Spring Harb Perspect Biol ISSN： 1943-0264 Impact factor: 10.005

9 in total

1. Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation.

Authors: Matthew Inlay; Frederick W Alt; David Baltimore; Yang Xu
Journal: Nat Immunol Date: 2002-04-22 Impact factor: 25.606

2. Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism.

Authors: R Sen; D Baltimore
Journal: Cell Date: 1986-12-26 Impact factor: 41.582

3. Multiple nuclear factors interact with the immunoglobulin enhancer sequences.

Authors: R Sen; D Baltimore
Journal: Cell Date: 1986-08-29 Impact factor: 41.582

4. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes.

Authors: H Singh; R Sen; D Baltimore; P A Sharp
Journal: Nature Date: 1986 Jan 9-15 Impact factor: 49.962

5. Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development.

Authors: E Siden; F W Alt; L Shinefeld; V Sato; D Baltimore
Journal: Proc Natl Acad Sci U S A Date: 1981-03 Impact factor: 11.205

6. Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement.

Authors: Y Xu; L Davidson; F W Alt; D Baltimore
Journal: Immunity Date: 1996-04 Impact factor: 31.745

7. Immunoglobulin gene transcription is activated by downstream sequence elements.

Authors: C Queen; D Baltimore
Journal: Cell Date: 1983-07 Impact factor: 41.582

8. I kappa B: a specific inhibitor of the NF-kappa B transcription factor.

Authors: P A Baeuerle; D Baltimore
Journal: Science Date: 1988-10-28 Impact factor: 47.728

9. Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor.

Authors: P A Baeuerle; D Baltimore
Journal: Cell Date: 1988-04-22 Impact factor: 41.582

9 in total

20 in total

Discovering NF-kappaB.

1. Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation.

2. Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism.

3. Multiple nuclear factors interact with the immunoglobulin enhancer sequences.

4. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes.

5. Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development.

6. Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement.

7. Immunoglobulin gene transcription is activated by downstream sequence elements.

8. I kappa B: a specific inhibitor of the NF-kappa B transcription factor.

9. Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor.

Review 1. The N-end rule pathway and regulation by proteolysis.

2. Redox Role of ROS and Inflammation in Pulmonary Diseases.

Review 3. Basic principles and emerging concepts in the redox control of transcription factors.

4. Single-nucleotide mutation matrix: a new model for predicting the NF-κB DNA binding sites.

5. Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma.

6. Sustained Inhibition of NF-κB Activity Mitigates Retinal Vasculopathy in Diabetes.

7. α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling.

8. Stimulation of innate immune cells by light-activated TLR7/8 agonists.

9. Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist.

10. TRAF6-mediated ubiquitination of NEMO requires p62/sequestosome-1.