| Literature DB >> 20065852 |
Aashiyana F Koreishi1, Adam J Saenz, Dan O Persky, Hayan Cui, Allison Moskowitz, Craig H Moskowitz, Julie Teruya-Feldstein.
Abstract
Recent data suggests the presence of cytotoxic (TIA-1 and granzyme B+) and regulatory T-cells (FOXP3+) in classical Hodgkin lymphoma (cHL) tissues has been shown to correlate with poor overall survival in mainly diagnostic biopsies. By tissue microarray analyses, we extend this observation to a cohort of relapsed/refractory cHL tissue biopsies and analyze immunohistochemical expression of FOXP3, TIA-1, and granzyme B in the inflammatory background and the tumor microenvironment. High expression of TIA-1 (>50%) correlated with poor overall survival (P<0.0001), low expression of FOXP3 (<25%) correlated with poor overall survival (P<0.01), and combined high TIA-1 (>50%) and low FOXP3 (<25%) correlated with poor overall survival (P<0.0001). Expression of cytotoxic and regulatory T-cells shows prognostic significance in the relapsed/refractory clinical setting of cHL.Entities:
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Year: 2010 PMID： 20065852 PMCID： PMC3260943 DOI： 10.1097/PAI.0b013e3181c7138b
Source DB: PubMed Journal: Appl Immunohistochem Mol Morphol ISSN： 1533-4058