BACKGROUND: Primary lateral sclerosis (PLS) is a progressive upper motor neuron neurodegenerative condition. The diagnosis is made using clinical history, objective neurological assessment, and exclusion of other neurodegenerative disorders. OBJECTIVE: To evaluate the role of fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection in the diagnosis of PLS. DESIGN: Case series. SETTING: Outpatient neurology clinic. Patients Three cases of probable PLS. Intervention Fluorodeoxyglucose F18 positron emission tomography in 3 patients with PLS. RESULTS: Three patients (2 male and 1 female; mean age, 65 years) were identified with a clinical diagnosis of PLS. Fluorodeoxyglucose F18 positron emission tomography demonstrated varying degrees of primary motor cortex hypometabolism. CONCLUSION: Fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection provide a useful diagnostic method to support a clinical diagnosis of PLS.
BACKGROUND:Primary lateral sclerosis (PLS) is a progressive upper motor neuron neurodegenerative condition. The diagnosis is made using clinical history, objective neurological assessment, and exclusion of other neurodegenerative disorders. OBJECTIVE: To evaluate the role of fluorodeoxyglucoseF18 positron emission tomography and 3-dimensional stereotactic surface projection in the diagnosis of PLS. DESIGN: Case series. SETTING:Outpatient neurology clinic. Patients Three cases of probable PLS. Intervention FluorodeoxyglucoseF18 positron emission tomography in 3 patients with PLS. RESULTS: Three patients (2 male and 1 female; mean age, 65 years) were identified with a clinical diagnosis of PLS. FluorodeoxyglucoseF18 positron emission tomography demonstrated varying degrees of primary motor cortex hypometabolism. CONCLUSION:FluorodeoxyglucoseF18 positron emission tomography and 3-dimensional stereotactic surface projection provide a useful diagnostic method to support a clinical diagnosis of PLS.
Authors: Eoin Finegan; Stacey Li Hi Shing; Rangariroyashe H Chipika; Kai Ming Chang; Mary Clare McKenna; Mark A Doherty; Jennifer C Hengeveld; Alice Vajda; Niall Pender; Colette Donaghy; Siobhan Hutchinson; Russell L McLaughlin; Orla Hardiman; Peter Bede Journal: Brain Imaging Behav Date: 2021-01-07 Impact factor: 3.978
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