BACKGROUND: Little is known about the clinical presentation and course of novel H1N1 influenza in summer camps. OBJECTIVES: To describe the clinical course and evaluate the effect of influenza treatment in a summer camp population. STUDY DESIGN: Two large influenza outbreaks occurred in university-based residential camps between May 21 and August 2, 2009. Through active daily surveillance, medical evaluation at symptom onset, and data collection during isolation, we describe the clinical course of a large outbreak of novel H1N1 influenza. RESULTS: Influenza-like illness (ILI) was documented in 119 individuals. Influenza A was confirmed in 66 (79%) of 84 samples tested. Three early samples were identified as novel H1N1. ILI cases had an average age of 15.7 years and 52% were male. Sixty-three were treated with oseltamivir or zanamivir, which was initiated within 24h of diagnosis. Cough, myalgia and sore throat occurred in 69, 64 and 63% of cases, respectively. The highest temperature over the course of illness (T(max)) occurred within 48h after symptom onset in 87.5% of individuals. Average T(max) was 38.4 degrees C (range 36.1-40.2 degrees C). Among confirmed influenza cases, 69% defervesced by 72h and 95% defervesced by 96h. Defervescence at 72h was not different in the treated and untreated groups (p=0.12). CONCLUSIONS: Novel H1N1 generally has a mild, self-limited course in healthy adolescent campers. Defervescence occurred within 72h and was unaffected by treatment.
BACKGROUND: Little is known about the clinical presentation and course of novel H1N1 influenza in summer camps. OBJECTIVES: To describe the clinical course and evaluate the effect of influenza treatment in a summer camp population. STUDY DESIGN: Two large influenza outbreaks occurred in university-based residential camps between May 21 and August 2, 2009. Through active daily surveillance, medical evaluation at symptom onset, and data collection during isolation, we describe the clinical course of a large outbreak of novel H1N1 influenza. RESULTS: Influenza-like illness (ILI) was documented in 119 individuals. Influenza A was confirmed in 66 (79%) of 84 samples tested. Three early samples were identified as novel H1N1. ILI cases had an average age of 15.7 years and 52% were male. Sixty-three were treated with oseltamivir or zanamivir, which was initiated within 24h of diagnosis. Cough, myalgia and sore throat occurred in 69, 64 and 63% of cases, respectively. The highest temperature over the course of illness (T(max)) occurred within 48h after symptom onset in 87.5% of individuals. Average T(max) was 38.4 degrees C (range 36.1-40.2 degrees C). Among confirmed influenza cases, 69% defervesced by 72h and 95% defervesced by 96h. Defervescence at 72h was not different in the treated and untreated groups (p=0.12). CONCLUSIONS: Novel H1N1 generally has a mild, self-limited course in healthy adolescent campers. Defervescence occurred within 72h and was unaffected by treatment.
Authors: John Neatherlin; Elaine H Cramer; Christine Dubray; Karen J Marienau; Michelle Russell; Hong Sun; Melissa Whaley; Kathy Hancock; Krista K Duong; Hannah L Kirking; Christopher Schembri; Jacqueline M Katz; Nicole J Cohen; Daniel B Fishbein Journal: Travel Med Infect Dis Date: 2013-03-21 Impact factor: 6.211
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Authors: Charles R Beck; Rachel Sokal; Nachiappan Arunachalam; Richard Puleston; Anna Cichowska; Anthony Kessel; Maria Zambon; Jonathan S Nguyen-Van-Tam Journal: Influenza Other Respir Viruses Date: 2013-01 Impact factor: 4.380
Authors: Daniel Bottomly; Martin T Ferris; Lauri D Aicher; Elizabeth Rosenzweig; Alan Whitmore; David L Aylor; Bart L Haagmans; Lisa E Gralinski; Birgit G Bradel-Tretheway; Janine T Bryan; David W Threadgill; Fernando Pardo-Manuel de Villena; Ralph S Baric; Michael G Katze; Mark Heise; Shannon K McWeeney Journal: G3 (Bethesda) Date: 2012-02-01 Impact factor: 3.154
Authors: Meagan Kay; Danielle M Zerr; Janet A Englund; Betsy L Cadwell; Jane Kuypers; Paul Swenson; Tao Sheng Kwan-Gett; Shaquita L Bell; Jeffrey S Duchin Journal: Emerg Infect Dis Date: 2011-04 Impact factor: 6.883
Authors: Martin T Ferris; David L Aylor; Daniel Bottomly; Alan C Whitmore; Lauri D Aicher; Timothy A Bell; Birgit Bradel-Tretheway; Janine T Bryan; Ryan J Buus; Lisa E Gralinski; Bart L Haagmans; Leonard McMillan; Darla R Miller; Elizabeth Rosenzweig; William Valdar; Jeremy Wang; Gary A Churchill; David W Threadgill; Shannon K McWeeney; Michael G Katze; Fernando Pardo-Manuel de Villena; Ralph S Baric; Mark T Heise Journal: PLoS Pathog Date: 2013-02-28 Impact factor: 6.823
Authors: Aharona Glatman-Freedman; Ian Portelli; Susan K Jacobs; Justin I Mathew; Jonathan E Slutzman; Lewis R Goldfrank; Silas W Smith Journal: PLoS One Date: 2012-11-30 Impact factor: 3.240