| Literature DB >> 20064714 |
Changyou Zhou1, Cheng Tang, Eric Chang, Min Ge, Songnian Lin, Eric Cline, Carina P Tan, Yue Feng, Yun-Ping Zhou, George J Eiermann, Aleksandr Petrov, Gino Salituro, Peter Meinke, Ralph Mosley, Taro E Akiyama, Monica Einstein, Sanjeev Kumar, Joel Berger, Andrew D Howard, Nancy Thornberry, Sander G Mills, Lihu Yang.
Abstract
Systematic structure-activity relationship (SAR) studies of a screening lead led to the discovery of a series of thiazolidinediones (TZDs) as potent GPR40 agonists. Among them, compound C demonstrated an acute mechanism-based glucose-lowering in an intraperitoneal glucose tolerance test (IPGTT) in lean mice, while no effects were observed in GPR40 knock-out mice. Copyright (c) 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 20064714 DOI： 10.1016/j.bmcl.2009.10.052
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823