Literature DB >> 20064381

alpha-synuclein and LRRK2: partners in crime.

Youren Tong1, Jie Shen.   

Abstract

In this issue of Neuron, Lin et al. report that LRRK2 modulates age-related neurodegeneration caused by overexpression of alpha-synuclein in the forebrain of transgenic mice. Overexpression of LRRK2 accelerates the progression of alpha-synuclein-mediated neuropathological changes, whereas deletion of LRRK2 alleviates these alterations. The results reveal an interesting interaction between alpha-synuclein and LRRK2, two gene products linked to dominantly inherited Parkinson's disease. 2009 Elsevier Inc. All rights reserved.

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Year:  2009        PMID： 20064381      PMCID： PMC2826885          DOI： 10.1016/j.neuron.2009.12.017

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  12 in total

1.  Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion.

Authors:  Nirmal Gosavi; He-Jin Lee; Jun Sung Lee; Smita Patel; Seung-Jae Lee
Journal:  J Biol Chem       Date:  2002-09-25       Impact factor: 5.157

2.  Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.

Authors:  Antony A Cooper; Aaron D Gitler; Anil Cashikar; Cole M Haynes; Kathryn J Hill; Bhupinder Bhullar; Kangning Liu; Kexiang Xu; Katherine E Strathearn; Fang Liu; Songsong Cao; Kim A Caldwell; Guy A Caldwell; Gerald Marsischky; Richard D Kolodner; Joshua Labaer; Jean-Christophe Rochet; Nancy M Bonini; Susan Lindquist
Journal:  Science       Date:  2006-06-22       Impact factor: 47.728

Review 3.  Altered alpha-synuclein homeostasis causing Parkinson's disease: the potential roles of dardarin.

Authors:  Andrew B Singleton
Journal:  Trends Neurosci       Date:  2005-08       Impact factor: 13.837

4.  Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration.

Authors:  Sreeganga Chandra; Gilbert Gallardo; Rafael Fernández-Chacón; Oliver M Schlüter; Thomas C Südhof
Journal:  Cell       Date:  2005-11-04       Impact factor: 41.582

5.  Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

Authors:  Xian Lin; Loukia Parisiadou; Xing-Long Gu; Lizhen Wang; Hoon Shim; Lixin Sun; Chengsong Xie; Cai-Xia Long; Wan-Jou Yang; Jinhui Ding; Zsu Zsu Chen; Paul E Gallant; Jung-Hwa Tao-Cheng; Gay Rudow; Juan C Troncoso; Zhihua Liu; Zheng Li; Huaibin Cai
Journal:  Neuron       Date:  2009-12-24       Impact factor: 17.173

Review 6.  The roles of kinases in familial Parkinson's disease.

Authors:  Mark R Cookson; William Dauer; Ted Dawson; Edward A Fon; Ming Guo; Jie Shen
Journal:  J Neurosci       Date:  2007-10-31       Impact factor: 6.167

7.  Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.

Authors:  Michael K Lee; Wanda Stirling; Yanqun Xu; Xueying Xu; Dike Qui; Allen S Mandir; Ted M Dawson; Neal G Copeland; Nancy A Jenkins; Don L Price
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-25       Impact factor: 11.205

8.  Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

Authors:  Benoit I Giasson; John E Duda; Shawn M Quinn; Bin Zhang; John Q Trojanowski; Virginia M-Y Lee
Journal:  Neuron       Date:  2002-05-16       Impact factor: 17.173

Review 9.  Mitochondria and dopamine: new insights into recessive parkinsonism.

Authors:  Jie Shen; Mark R Cookson
Journal:  Neuron       Date:  2004-08-05       Impact factor: 17.173

10.  R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

Authors:  Youren Tong; Antonio Pisani; Giuseppina Martella; Maha Karouani; Hiroo Yamaguchi; Emmanuel N Pothos; Jie Shen
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-10       Impact factor: 11.205
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  11 in total

Review 1.  Diabetes type II: a risk factor for depression-Parkinson-Alzheimer?

Authors:  Peter Riederer; Jasmin Bartl; Gerd Laux; Edna Grünblatt
Journal:  Neurotox Res       Date:  2010-06-15       Impact factor: 3.911

2.  The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway.

Authors:  José M Bravo-San Pedro; Mireia Niso-Santano; Rubén Gómez-Sánchez; Elisa Pizarro-Estrella; Ana Aiastui-Pujana; Ana Gorostidi; Vicente Climent; Rakel López de Maturana; Rosario Sanchez-Pernaute; Adolfo López de Munain; José M Fuentes; Rosa A González-Polo
Journal:  Cell Mol Life Sci       Date:  2012-07-08       Impact factor: 9.261

Review 3.  Gene-environment interactions: key to unraveling the mystery of Parkinson's disease.

Authors:  Hui-Ming Gao; Jau-Shyong Hong
Journal:  Prog Neurobiol       Date:  2011-03-23       Impact factor: 11.685

4.  G2019S LRRK2 Mutation Enhances MPP+-Induced Inflammation of Human Induced Pluripotent Stem Cells-Differentiated Dopaminergic Neurons.

Authors:  Ying Chen; Qing Yin; Xiao-Yu Cheng; Jin-Ru Zhang; Hong Jin; Kai Li; Cheng-Jie Mao; Fen Wang; Hong-Zhe Bei; Chun-Feng Liu
Journal:  Front Neurosci       Date:  2022-07-06       Impact factor: 5.152

Review 5.  Animal models of Parkinson's disease: vertebrate genetics.

Authors:  Yunjong Lee; Valina L Dawson; Ted M Dawson
Journal:  Cold Spring Harb Perspect Med       Date:  2012-10-01       Impact factor: 6.915

6.  Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.

Authors:  Mansoureh Hakimi; Thirumahal Selvanantham; Erika Swinton; Ruth F Padmore; Youren Tong; Ghassan Kabbach; Katerina Venderova; Stephen E Girardin; Dennis E Bulman; Clemens R Scherzer; Matthew J LaVoie; Denis Gris; David S Park; Jonathan B Angel; Jie Shen; Dana J Philpott; Michael G Schlossmacher
Journal:  J Neural Transm (Vienna)       Date:  2011-05-07       Impact factor: 3.575

7.  The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.

Authors:  S Saez-Atienzar; L Bonet-Ponce; J R Blesa; F J Romero; M P Murphy; J Jordan; M F Galindo
Journal:  Cell Death Dis       Date:  2014-08-14       Impact factor: 8.469

Review 8.  Genetics and genomics of Parkinson's disease.

Authors:  Michelle K Lin; Matthew J Farrer
Journal:  Genome Med       Date:  2014-06-30       Impact factor: 11.117

9.  Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain.

Authors:  Qing Xie; Ying Yang; Jie Huang; Jovica Ninkovic; Tessa Walcher; Louise Wolf; Ariel Vitenzon; Deyou Zheng; Magdalena Götz; David C Beebe; Jiri Zavadil; Ales Cvekl
Journal:  PLoS One       Date:  2013-01-14       Impact factor: 3.240

Review 10.  Mouse Genetic Models of Human Brain Disorders.

Authors:  Celeste Leung; Zhengping Jia
Journal:  Front Genet       Date:  2016-03-23       Impact factor: 4.599
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