OBJECTIVE:Medication nonadherence has been a persistent problem over the past three decades; forgetting and being distracted from regular routines are the barriers most frequently cited by patients. Prior research on cognitive function and medication adherence has yielded mixed results. DESIGN: This report compares findings of three studies: All were longitudinal, two were randomized controlled intervention trials, and one was descriptive. Samples of adult patients taking once daily lipid-lowering medication, diabetic patients with comorbid conditions on complex regimens, and early stage breast cancer patients on hormonal therapy completed similar batteries of standardized, valid, neuropsychological tests at baseline. MAIN OUTCOME MEASURES: Adherence to medication regimens, over time, was tracked with electronic event monitors. RESULTS:Medication nonadherence was prevalent in all studies. Deficits in attention/mental flexibility and/or working memory predicted nonadherence in all studies; impaired executive function was related to poor adherence in one study. CONCLUSION: These findings suggest that better mental efficiency may be the key to better medication adherence with any regimen, and that targeted cognitive functions, which can be easily and quickly assessed, may identify patients at risk of poor adherence regardless of diagnosis or regimen.
RCT Entities:
OBJECTIVE: Medication nonadherence has been a persistent problem over the past three decades; forgetting and being distracted from regular routines are the barriers most frequently cited by patients. Prior research on cognitive function and medication adherence has yielded mixed results. DESIGN: This report compares findings of three studies: All were longitudinal, two were randomized controlled intervention trials, and one was descriptive. Samples of adult patients taking once daily lipid-lowering medication, diabeticpatients with comorbid conditions on complex regimens, and early stage breast cancerpatients on hormonal therapy completed similar batteries of standardized, valid, neuropsychological tests at baseline. MAIN OUTCOME MEASURES: Adherence to medication regimens, over time, was tracked with electronic event monitors. RESULTS: Medication nonadherence was prevalent in all studies. Deficits in attention/mental flexibility and/or working memory predicted nonadherence in all studies; impaired executive function was related to poor adherence in one study. CONCLUSION: These findings suggest that better mental efficiency may be the key to better medication adherence with any regimen, and that targeted cognitive functions, which can be easily and quickly assessed, may identify patients at risk of poor adherence regardless of diagnosis or regimen.
Authors: Terry R Barclay; Charles H Hinkin; Steven A Castellon; Karen I Mason; Matthew J Reinhard; Sarah D Marion; Andrew J Levine; Ramani S Durvasula Journal: Health Psychol Date: 2007-01 Impact factor: 4.267
Authors: Catherine M Bender; Susan M Sereika; Adam M Brufsky; Christopher M Ryan; Victor G Vogel; Priya Rastogi; Susan M Cohen; Frances E Casillo; Sarah L Berga Journal: Menopause Date: 2007 Nov-Dec Impact factor: 2.953
Authors: Tara A Burra; Edmund Chen; Roger S McIntyre; Sherry L Grace; Emma Robertson Blackmore; Donna E Stewart Journal: Behav Med Date: 2007 Impact factor: 3.104
Authors: Arti Hurria; Ilene S Browner; Harvey Jay Cohen; Crystal S Denlinger; Mollie deShazo; Martine Extermann; Apar Kishor P Ganti; Jimmie C Holland; Holly M Holmes; Mohana B Karlekar; Nancy L Keating; June McKoy; Bruno C Medeiros; Ewa Mrozek; Tracey O'Connor; Stephen H Petersdorf; Hope S Rugo; Rebecca A Silliman; William P Tew; Louise C Walter; Alva B Weir; Tanya Wildes Journal: J Natl Compr Canc Netw Date: 2012-02 Impact factor: 11.908
Authors: Mackenzi Pergolotti; Nicolò Matteo Luca Battisti; Lynne Padgett; Alix G Sleight; Maya Abdallah; Robin Newman; Kathleen Van Dyk; Kelley R Covington; Grant R Williams; Frederiek van den Bos; YaoYao Pollock; Elizabeth A Salerno; Allison Magnuson; Isabella F Gattás-Vernaglia; Tim A Ahles Journal: J Geriatr Oncol Date: 2019-10-14 Impact factor: 3.599
Authors: Karen M Mustian; Calvin L Cole; Po Ju Lin; Matt Asare; Chunkit Fung; Michelle C Janelsins; Charles S Kamen; Luke J Peppone; Allison Magnuson Journal: Semin Oncol Nurs Date: 2016-10-21 Impact factor: 2.315
Authors: Erum A Hartung; Guray Erus; Abbas F Jawad; Nina Laney; Jimit J Doshi; Stephen R Hooper; Jerilynn Radcliffe; Christos Davatzikos; Susan L Furth Journal: Am J Kidney Dis Date: 2018-02-15 Impact factor: 8.860
Authors: Kah Poh Loh; Michelle C Janelsins; Supriya G Mohile; Holly M Holmes; Tina Hsu; Sharon K Inouye; Meghan S Karuturi; Gretchen G Kimmick; Stuart M Lichtman; Allison Magnuson; Mary I Whitehead; Melisa L Wong; Tim A Ahles Journal: J Geriatr Oncol Date: 2016-07-05 Impact factor: 3.599