Literature DB >> 2006240

Pindolol decreases prolactin and growth hormone responses to intravenous L-tryptophan.

C E Smith1, C J Ware, P J Cowen.   

Abstract

The effects of pindolol on the prolactin (PRL) and growth hormone (GH) responses to intravenous tryptophan (LTP) were studied in eight healthy male volunteers. Pindolol pretreatment (40 mg over 48 h) markedly attenuated the GH response to LTP and modestly, but significantly, reduced the LTP-induced increase in plasma PRL. The disposition of LTP following infusion was not altered by pindolol. While the data are consistent with 5-HT1A receptor mediation of PRL and GH responses to LTP, the intrinsic sympathomimetic actions of pindolol might also be involved in the attenuation of the endocrine responses to LTP.

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Year:  1991        PMID： 2006240     DOI： 10.1007/bf02244090

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  13 in total

1.  The effect of metergoline on endocrine responses to L-tryptophan.

Authors:  S L McCance; P J Cowen; H Waller; D G Grahame-Smith
Journal:  J Psychopharmacol       Date:  1987-01       Impact factor: 4.153

2.  Error in the determination of tryptophan by the method of Denkla and Dewey. A revised procedure.

Authors:  D L Bloxam; W H Warren
Journal:  Anal Biochem       Date:  1974-08       Impact factor: 3.365

Review 3.  The influence of psychotropic drugs and releasing hormones on anterior pituitary hormone secretion in healthy subjects and depressed patients.

Authors:  G Laakmann; A Hinz; U Voderholzer; C Daffner; O A Müller; H Neuhauser; E Neulinger; M Wittmann
Journal:  Pharmacopsychiatry       Date:  1990-01       Impact factor: 5.788

4.  Clomipramine enhances prolactin and growth hormone responses to L-tryptophan.

Authors:  I M Anderson; P J Cowen
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

5.  Serotonergic function in depression. Prolactin response to intravenous tryptophan in depressed patients and healthy subjects.

Authors:  G R Heninger; D S Charney; D E Sternberg
Journal:  Arch Gen Psychiatry       Date:  1984-04

6.  beta-Adrenoceptor blocking activity and duration of action of pindolol and propranolol in healthy volunteers.

Authors:  W H Aellig
Journal:  Br J Clin Pharmacol       Date:  1976-04       Impact factor: 4.335

7.  A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation.

Authors:  J F Deakin; I Pennell; A J Upadhyaya; R Lofthouse
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

8.  Neuroendocrine responses to intravenous tryptophan in major depression.

Authors:  P J Cowen; E M Charig
Journal:  Arch Gen Psychiatry       Date:  1987-11

9.  The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat.

Authors:  M D Tricklebank; C Forler; J R Fozard
Journal:  Eur J Pharmacol       Date:  1984-11-13       Impact factor: 4.432

10.  Stimulation of corticosterone and beta-endorphin secretion in the rat by selective 5-HT receptor subtype activation.

Authors:  J I Koenig; G A Gudelsky; H Y Meltzer
Journal:  Eur J Pharmacol       Date:  1987-05-07       Impact factor: 4.432
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  12 in total

1.  Effect of pindolol on endocrine and temperature responses to buspirone in healthy volunteers.

Authors:  I M Anderson; P J Cowen
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

2.  Lithium and 5-HT1A receptor sensitivity: a neuroendocrine study in healthy volunteers.

Authors:  A E Walsh; C J Ware; P J Cowen
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

3.  EEG effects of buspirone and pindolol: a method of examining 5-HT1A receptor function in humans.

Authors:  R H McAllister-Williams; A E Massey
Journal:  Psychopharmacology (Berl)       Date:  2003-02-13       Impact factor: 4.530

4.  Effect of pindolol on hormone secretion and body temperature: partial agonist effects.

Authors:  H Y Meltzer; M Maes
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

5.  Elevated prolactin responses to L-tryptophan infusion in medication-free depressed patients.

Authors:  Richard J Porter; Peter Gallagher; Stuart Watson; Margaret S Smith; Allan H Young
Journal:  Psychopharmacology (Berl)       Date:  2003-05-01       Impact factor: 4.530

6.  5-HT2a/2c receptor blockade by amesergide fully attenuates prolactin response to d-fenfluramine challenge in physically healthy human subjects.

Authors:  E F Coccaro; R J Kavoussi; M Oakes; T B Cooper; R Hauger
Journal:  Psychopharmacology (Berl)       Date:  1996-07       Impact factor: 4.530

Review 7.  Corticosteroid-serotonin interactions in depression: a review of the human evidence.

Authors:  Richard J Porter; Peter Gallagher; Stuart Watson; Allan H Young
Journal:  Psychopharmacology (Berl)       Date:  2004-03-09       Impact factor: 4.530

8.  Crossroads of corticotropin releasing hormone, corticosteroids and monoamines. About a biological interface between stress and depression.

Authors:  H. M. Van Praag
Journal:  Neurotox Res       Date:  2002 Aug-Sep       Impact factor: 3.911

9.  Effect of pindolol on the L-5-HTP-induced increase in plasma prolactin and cortisol concentrations in man.

Authors:  H Y Meltzer; M Maes
Journal:  Psychopharmacology (Berl)       Date:  1994-05       Impact factor: 4.530

10.  Effects of imipramine on serotonergic and beta-adrenergic receptor binding in a realistic animal model of depression.

Authors:  M Papp; V Klimek; P Willner
Journal:  Psychopharmacology (Berl)       Date:  1994-03       Impact factor: 4.530
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