INTRODUCTION: Pandemic Influenza A (H1N1)v infection is the first pandemic in which intensive care units (ICU) play a fundamental role. It has spread very rapidly since the first cases were diagnosed in Mexico with the subsequent spread of the virus throughout the Southern Cone and Europe during the summer season. OBJECTIVE: This study has aimed to compare the clinical presentation and outcome among the critical patients admitted to the ICU until July 31, 2009 in Spain with some series from Latin America. MATERIAL AND METHOD: Six series of critically ill patients admitted to the ICU were considered. Clinical characteristics, complications and outcome were compared between series. RESULTS: Young patients (35-45 years) with viral pneumonia as a predominant ICU admission cause with severe respiratory failure and a high need of mechanical ventilation (60-100%) were affected. Obesity, pregnancy and chronic lung disease were risk factors associated with a worse outcome, however there was a high number of patients without comorbidities (40-50%). Mortality rate was between 25-50% and higher in the Latin America series, demonstrating the specific potential pathogenesis of the new virus. The use of antiviral treatment was delayed (between 3 and 6 days) and not generalized, with greater delay in Latin America in regards to Spain. CONCLUSIONS: These data suggest that a more aggressive treatment strategy, with earlier and easier access to the antiviral treatment might reduce the number of ICU admissions and mortality. Copyright 2009 Elsevier España, S.L. y SEMICYUC. All rights reserved.
INTRODUCTION: Pandemic Influenza A (H1N1)v infection is the first pandemic in which intensive care units (ICU) play a fundamental role. It has spread very rapidly since the first cases were diagnosed in Mexico with the subsequent spread of the virus throughout the Southern Cone and Europe during the summer season. OBJECTIVE: This study has aimed to compare the clinical presentation and outcome among the critical patients admitted to the ICU until July 31, 2009 in Spain with some series from Latin America. MATERIAL AND METHOD: Six series of critically illpatients admitted to the ICU were considered. Clinical characteristics, complications and outcome were compared between series. RESULTS: Young patients (35-45 years) with viral pneumonia as a predominant ICU admission cause with severe respiratory failure and a high need of mechanical ventilation (60-100%) were affected. Obesity, pregnancy and chronic lung disease were risk factors associated with a worse outcome, however there was a high number of patients without comorbidities (40-50%). Mortality rate was between 25-50% and higher in the Latin America series, demonstrating the specific potential pathogenesis of the new virus. The use of antiviral treatment was delayed (between 3 and 6 days) and not generalized, with greater delay in Latin America in regards to Spain. CONCLUSIONS: These data suggest that a more aggressive treatment strategy, with earlier and easier access to the antiviral treatment might reduce the number of ICU admissions and mortality. Copyright 2009 Elsevier España, S.L. y SEMICYUC. All rights reserved.
Authors: B Sertogullarindan; B Ozbay; H Gunini; A Sunnetcioglu; A Arisoy; H M Bilgin; B Mermit Cilingir; M Duran; H Yildiz; S Ekin; Ai Baran Journal: Afr Health Sci Date: 2011-06 Impact factor: 0.927
Authors: Maria D Van Kerkhove; Katelijn A H Vandemaele; Vivek Shinde; Giovanna Jaramillo-Gutierrez; Artemis Koukounari; Christl A Donnelly; Luis O Carlino; Rhonda Owen; Beverly Paterson; Louise Pelletier; Julie Vachon; Claudia Gonzalez; Yu Hongjie; Feng Zijian; Shuk Kwan Chuang; Albert Au; Silke Buda; Gerard Krause; Walter Haas; Isabelle Bonmarin; Kiyosu Taniguichi; Kensuke Nakajima; Tokuaki Shobayashi; Yoshihiro Takayama; Tomi Sunagawa; Jean Michel Heraud; Arnaud Orelle; Ethel Palacios; Marianne A B van der Sande; C C H Lieke Wielders; Darren Hunt; Jeffrey Cutter; Vernon J Lee; Juno Thomas; Patricia Santa-Olalla; Maria J Sierra-Moros; Wanna Hanshaoworakul; Kumnuan Ungchusak; Richard Pebody; Seema Jain; Anthony W Mounts Journal: PLoS Med Date: 2011-07-05 Impact factor: 11.069
Authors: Miguel Delgado-Rodríguez; Jesús Castilla; Pere Godoy; Vicente Martín; Nuria Soldevila; Jordi Alonso; Jenaro Astray; Maretva Baricot; Rafael Cantón; Ady Castro; Fernando Gónzález-Candelas; José María Mayoral; José María Quintana; Tomás Pumarola; Sonia Tamames; Marc Sáez; Angela Domínguez Journal: J Antimicrob Chemother Date: 2012-03-30 Impact factor: 5.790
Authors: Miguel Delgado-Rodríguez; Jesús Castilla; Pere Godoy; Vicente Martín; Nuria Soldevila; Jordi Alonso; Jenaro Astray; Maretva Baricot; Juan C Galán; Ady Castro; Fernando Gónzález-Candelas; José M Mayoral; José M Quintana; Tomás Pumarola; Sonia Tamames; Marc Sáez; Angela Domínguez Journal: Influenza Other Respir Viruses Date: 2013-05-04 Impact factor: 4.380