Literature DB >> 20060812

Repressive BMP2 gene regulatory elements near the BMP2 promoter.

Shan Jiang1, Ronald L Chandler, David T Fritz, Douglas P Mortlock, Melissa B Rogers.   

Abstract

The level of bone morphogenetic protein 2 (BMP2) profoundly influences essential cell behaviors such as proliferation, differentiation, apoptosis, and migration. The spatial and temporal pattern of BMP2 synthesis, particular in diverse embryonic cells, is highly varied and dynamic. We have identified GC-rich sequences within the BMP2 promoter region that strongly repress gene expression. These elements block the activity of a highly conserved, osteoblast enhancer in response to FGF2 treatment. Both positive and negative gene regulatory elements control BMP2 synthesis. Detecting and mapping the repressive motifs is essential because they impede the identification of developmentally regulated enhancers necessary for normal BMP2 patterns and concentration. 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20060812      PMCID： PMC2822113          DOI： 10.1016/j.bbrc.2009.12.157

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  45 in total

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Review 3.  Gradients and thresholds: BMP response gradients unveiled in Drosophila embryos.

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5.  Autoregulation of mouse BMP-2 gene transcription is directed by the proximal promoter element.

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Journal:  Biochem Biophys Res Commun       Date:  2001-08-10       Impact factor: 3.575

Review 6.  Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation.

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8.  BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect.

Authors:  Andrew R Hallahan; Joel I Pritchard; Roshantha A S Chandraratna; Richard G Ellenbogen; J Russel Geyer; Ryan P Overland; Andrew D Strand; Stephen J Tapscott; James M Olson
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9.  NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro.

Authors:  Jian Q Feng; Lianping Xing; Jiang-Hong Zhang; Ming Zhao; Diane Horn; Jeannie Chan; Brendan F Boyce; Stephen E Harris; Gregory R Mundy; Di Chen
Journal:  J Biol Chem       Date:  2003-05-20       Impact factor: 5.157

10.  Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes.

Authors:  Naoshi Fukui; Yong Zhu; William J Maloney; John Clohisy; Linda J Sandell
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  4 in total

1.  An autonomous BMP2 regulatory element in mesenchymal cells.

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Journal:  J Cell Biochem       Date:  2011-02       Impact factor: 4.429

Review 2.  Turning Bone Morphogenetic Protein 2 (BMP2) on and off in Mesenchymal Cells.

Authors:  Melissa B Rogers; Tapan A Shah; Nadia N Shaikh
Journal:  J Cell Biochem       Date:  2015-10       Impact factor: 4.429

3.  Epigenetic regulation of BMP2 by 1,25-dihydroxyvitamin D3 through DNA methylation and histone modification.

Authors:  Baisheng Fu; Hongwei Wang; Jinhua Wang; Ivana Barouhas; Wanqing Liu; Adam Shuboy; David A Bushinsky; Dongsheng Zhou; Murray J Favus
Journal:  PLoS One       Date:  2013-04-19       Impact factor: 3.240

4.  Comparative genomics identifies the mouse Bmp3 promoter and an upstream evolutionary conserved region (ECR) in mammals.

Authors:  Jonathan W Lowery; Anna W Lavigne; Shoichiro Kokabu; Vicki Rosen
Journal:  PLoS One       Date:  2013-02-22       Impact factor: 3.240
  4 in total

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