Literature DB >> 20060780

AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease.

Chunying Li1, John F Keaney.   

Abstract

AMP-activated protein kinase (AMPK) was initially viewed as energy sensor and activated by increased intracellular concentrations of AMP following nutrient deprivation. Physiological or pathological stimuli that deplete cellular energy activate AMPK that coordinates a cellular program that limits further ATP depletion and promotes compensatory changes that maintain cellular ATP levels. Recent studies revealed novel roles of AMPK independent of energy status, thereby increasing our understanding of multi-functional roles of AMPK in cells important in pathogenesis of cardiovascular diseases. This enzyme represents an attractive therapeutic target for vascular disease treatment in the future. Copyright 2009 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  AMPK; cardiovascular disease; stress

Mesh：

Substances：

Year:  2010        PMID： 20060780      PMCID： PMC2843779          DOI： 10.1016/j.coph.2009.11.009

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  41 in total

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