| Literature DB >> 20060381 |
Lin Liu1, Baoan Chen, Shukui Qin, Suyi Li, Xiangming He, Shaomin Qiu, Wei Zhao, Hong Zhao.
Abstract
Many studies have demonstrated that histone deacetylase (HDAC) inhibitors induce various tumor cells to undergo apoptosis, and such inhibitors have been used in different clinical trials against different human cancers. In this study, we designed and synthesized a novel HDAC inhibitor, Chidamide. We showed that Chidamide was able to increase the acetylation levels of histone H3 and to inhibit the PI3K/Akt and MAPK/Ras signaling pathways, which resulted in arresting colon cancer cells at the G1 phase of the cell cycle and promoting apoptosis. As a result, the proliferation of colon cancer cells was suppressed in vitro. Our data support the potential application of Chidamide as an anticancer agent in treating colon cancer. Future studies are needed to demonstrate its in vivo efficacy. 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20060381 DOI： 10.1016/j.bbrc.2010.01.011
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575