OBJECTIVE: Osteoporosis is a common disorder with a strong genetic component. The genetics of osteoporosis impacts on the prediction, diagnosis, prognosis, and treatment of the disease. STUDY DESIGN: The aim of the present study was to examine associations between cytokine gene polymorphisms (IL-1beta, IL-2, IL-6) and bone mineral density (BMD) values in postmenopausal women. The study included 226 postmenopausal women with a diagnosed BMD T-score lower than -2.5 SD (mean: -3.02+/-.053) and 224 postmenopausal women with a BMD T-score greater than -2.5 SD (mean: -1.33+/-0.51). RESULTS: Among the women with T-scores below -2.5 SD, the BMD values were significantly lower in the carriers of the IL-6 GG genotype compared with those with the CC and GC genotypes (0.70+/-0.38 vs. 0.73+/-0.25 and 0.74+/-0.23 for the lumbar spine, 0.54+/-0.18 vs. 0.56+/-0.15 and 0.58+/-0.22 for the femoral neck). There were no statistically significant associations between the IL-1beta and IL-2 genotypes and BMD values in the group of women with T-scores below -2.5 SD. CONCLUSION: The results of the present study suggest an association of the IL-6 -174 G/C polymorphism with osteoporosis in postmenopausal women. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
OBJECTIVE:Osteoporosis is a common disorder with a strong genetic component. The genetics of osteoporosis impacts on the prediction, diagnosis, prognosis, and treatment of the disease. STUDY DESIGN: The aim of the present study was to examine associations between cytokine gene polymorphisms (IL-1beta, IL-2, IL-6) and bone mineral density (BMD) values in postmenopausal women. The study included 226 postmenopausal women with a diagnosed BMD T-score lower than -2.5 SD (mean: -3.02+/-.053) and 224 postmenopausal women with a BMD T-score greater than -2.5 SD (mean: -1.33+/-0.51). RESULTS: Among the women with T-scores below -2.5 SD, the BMD values were significantly lower in the carriers of the IL-6 GG genotype compared with those with the CC and GC genotypes (0.70+/-0.38 vs. 0.73+/-0.25 and 0.74+/-0.23 for the lumbar spine, 0.54+/-0.18 vs. 0.56+/-0.15 and 0.58+/-0.22 for the femoral neck). There were no statistically significant associations between the IL-1beta and IL-2 genotypes and BMD values in the group of women with T-scores below -2.5 SD. CONCLUSION: The results of the present study suggest an association of the IL-6-174 G/C polymorphism with osteoporosis in postmenopausal women. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Authors: N Ahmadi; S S Mao; F Hajsadeghi; B Arnold; S Kiramijyan; Y Gao; F Flores; S Azen; M Budoff Journal: Osteoporos Int Date: 2018-04-27 Impact factor: 4.507
Authors: C A D Lima; N R Javorski; A P O Souza; A D Barbosa; A P M C Valença; S Crovella; P R E Souza; J De Azevedo Silva; P Sandrin-Garcia Journal: Inflammopharmacology Date: 2017-02-21 Impact factor: 4.473