| Literature DB >> 20060185 |
Masatsugu Ohtsuki1, Shin-Ichiro Morimoto2, Hideo Izawa3, Tevfik F Ismail4, Hatsue Ishibashi-Ueda5, Yasuchika Kato2, Taiko Horii6, Tadashi Isomura7, Hisayoshi Suma8, Masanori Nomura3, Hitoshi Hishida2, Hiroki Kurahashi9, Yukio Ozaki10.
Abstract
It has been reported that angiotensin converting enzyme (ACE) 2, a homologue of ACE, has direct effects on cardiac function. However, the role of ACE2 in the development of human heart failure is not fully understood. We evaluated the expression of the ACE2 gene by means of real-time RT-PCR in myocardium from 14 patients with end-stage heart failure. The amount of ACE2 mRNA positively correlated with left ventricular (LV) end-diastolic diameter (r(2)=0.56, p<0.01) but did not significantly correlate with LV ejection fraction or plasma brain natriuretic peptide levels. In conclusion, our data show that the up-regulation of the ACE2 gene in the LV myocardium of patients with severe heart failure was associated with the degree of LV dilatation and may thereby constitute an important adaptive mechanism to retard the progression of adverse LV remodeling.Entities:
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Year: 2010 PMID： 20060185 DOI： 10.1016/j.ijcard.2009.11.057
Source DB: PubMed Journal: Int J Cardiol ISSN： 0167-5273 Impact factor: 4.164