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Literature DB >> 20059995

NMY-2 maintains cellular asymmetry and cell boundaries, and promotes a SRC-dependent asymmetric cell division.

Ji Liu¹, Lisa L Maduzia, Masaki Shirayama, Craig C Mello.

Abstract

The nonmuscle myosin II NMY-2 is required for cytokinesis as well as for the establishment of zygote asymmetry during embryogenesis in Caenorhabditis elegans. Here we describe two conditional nmy-2 alleles that rapidly and reversibly inactivate the protein. We show that NMY-2 has late-cell-cycle roles in maintaining embryonic asymmetries and is also required for a surprisingly late step in the maintenance of the cytokinesis furrow. Finally, during a signaling-induced asymmetric cell division, NMY-2 is required for SRC-dependent phosphotyrosine signaling and acts in parallel with WNT-signaling to specify endoderm. Copyright 2010 Elsevier Inc. All rights reserved.

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Year: 2010 PMID： 20059995 PMCID： PMC2903000 DOI： 10.1016/j.ydbio.2009.12.041

Source DB: PubMed Journal: Dev Biol ISSN： 0012-1606 Impact factor: 3.582

34 in total

1. The requirement for mechanical coupling between head and S2 domains in smooth muscle myosin ATPase regulation and its implications for dimeric motor function.

Authors: Florence Tama; Michael Feig; Jun Liu; Charles L Brooks; Kenneth A Taylor
Journal: J Mol Biol Date: 2005-01-28 Impact factor: 5.469

Review 2. The molecular requirements for cytokinesis.

Authors: Michael Glotzer
Journal: Science Date: 2005-03-18 Impact factor: 47.728

3. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

Authors: A Fire; S Xu; M K Montgomery; S A Kostas; S E Driver; C C Mello
Journal: Nature Date: 1998-02-19 Impact factor: 49.962

4. Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm.

Authors: C J Thorpe; A Schlesinger; J C Carter; B Bowerman
Journal: Cell Date: 1997-08-22 Impact factor: 41.582

5. Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos.

Authors: C E Rocheleau; W D Downs; R Lin; C Wittmann; Y Bei; Y H Cha; M Ali; J R Priess; C C Mello
Journal: Cell Date: 1997-08-22 Impact factor: 41.582

6. Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4.

Authors: W B Raich; A N Moran; J H Rothman; J Hardin
Journal: Mol Biol Cell Date: 1998-08 Impact factor: 4.138

7. A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans.

Authors: S Guo; K J Kemphues
Journal: Nature Date: 1996-08-01 Impact factor: 49.962

8. An analysis of the response to gut induction in the C. elegans embryo.

Authors: B Goldstein
Journal: Development Date: 1995-04 Impact factor: 6.868

9. PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos.

Authors: L Boyd; S Guo; D Levitan; D T Stinchcomb; K J Kemphues
Journal: Development Date: 1996-10 Impact factor: 6.868

10. Cell contacts orient some cell division axes in the Caenorhabditis elegans embryo.

Authors: B Goldstein
Journal: J Cell Biol Date: 1995-05 Impact factor: 10.539

25 in total

1. Internalization of multiple cells during C. elegans gastrulation depends on common cytoskeletal mechanisms but different cell polarity and cell fate regulators.

Authors: Jessica R Harrell; Bob Goldstein
Journal: Dev Biol Date: 2010-09-26 Impact factor: 3.582

2. The kinases PIG-1 and PAR-1 act in redundant pathways to regulate asymmetric division in the EMS blastomere of C. elegans.

Authors: Małgorzata J Liro; Diane G Morton; Lesilee S Rose
Journal: Dev Biol Date: 2018-09-10 Impact factor: 3.582

3. The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.

Authors: Alexander Beatty; Diane Morton; Kenneth Kemphues
Journal: Development Date: 2010-11-01 Impact factor: 6.868

4. Another morphogenetic movement on the map: Charting dorsal intercalation in C. elegans.

Authors: Elise Walck-Shannon; Jeff Hardin
Journal: Worm Date: 2016-04-12

5. Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization.

Authors: Shyi-Chyi Wang; Tricia Yu Feng Low; Yukako Nishimura; Laurent Gole; Weimiao Yu; Fumio Motegi
Journal: Nat Cell Biol Date: 2017-07-24 Impact factor: 28.824

6. PAR-3 oligomerization may provide an actin-independent mechanism to maintain distinct par protein domains in the early Caenorhabditis elegans embryo.

Authors: Adriana T Dawes; Edwin M Munro
Journal: Biophys J Date: 2011-09-20 Impact factor: 4.033