Literature DB >> 20059757

Analysis of Wnt pathway genes during ex vivo expansion and neutrophil differentiation of umbilical-cord-blood-derived CD34 cells.

R C J Gallagher1, O Tura-Ceide, M Turner, R Barclay.   

Abstract

Previous work has shown that optimal ex vivo expansion and differentiation of CD34(+) progenitor cells into neutrophils is by addition of Flt3-L, SCF and G-CSF. Here we report that a variety of genes involved in the WNT pathway are transcriptionally active in both undifferentiated and differentiated umbilical cord blood CD34(+) cells, however statistically significant changes in gene expression are not always consistent across UCB samples.

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Year:  2010        PMID: 20059757     DOI: 10.1111/j.1423-0410.2009.01299.x

Source DB:  PubMed          Journal:  Vox Sang        ISSN: 0042-9007            Impact factor:   2.144


  3 in total

Review 1.  The hematopoietic system in the context of regenerative medicine.

Authors:  Christopher D Porada; Anthony J Atala; Graça Almeida-Porada
Journal:  Methods       Date:  2015-08-28       Impact factor: 3.608

2.  Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice.

Authors:  Quyen Cheng; Ze'ev Seltzer; Corneliu Sima; Flavia S Lakschevitz; Michael Glogauer
Journal:  PLoS One       Date:  2015-05-05       Impact factor: 3.240

3.  Modeling Transcriptional Rewiring in Neutrophils Through the Course of Treated Juvenile Idiopathic Arthritis.

Authors:  Zihua Hu; Kaiyu Jiang; Mark Barton Frank; Yanmin Chen; James N Jarvis
Journal:  Sci Rep       Date:  2018-05-17       Impact factor: 4.379

  3 in total

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