Literature DB >> 20058468

Lumbar discal herniation in the elderly: long-term results of chymopapain chemonucleolysis.

M Benoist1, H Parent, M Nizard, B Lassale, A Deburge.   

Abstract

Very few reports in the literature have dealt with lumbar disc herniation in the elderly and its treatment by chymopapain chemonucleolysis. Between September 1981 and May 1991, 42 patients aged between 60 and 80 years were treated by chemonucleolysis for lumbar disc herniation. The clinical symptoms and signs, similar to those observed in younger patients, were well correlated with a clear picture of discal herniation on the CT scan without any associated stenosis. At the last follow-up (mean 4.5 years) satisfactory results were obtained in 78% of the patients. No complication were observed. It is concluded that in the rare cases of discal herniation in the elderly, chymopapain chemonucleolysis should be considered as a safe and efficacious alternative to surgery.

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Year:  1993        PMID: 20058468     DOI: 10.1007/bf00301413

Source DB:  PubMed          Journal:  Eur Spine J        ISSN: 0940-6719            Impact factor:   3.134


  15 in total

1.  Treatment of low back and sciatic pain in patients over 60 years of age. A study of 100 patients.

Authors:  J S BARR; E J RISEBOROUGH
Journal:  Clin Orthop Relat Res       Date:  1963       Impact factor: 4.176

2.  A pathologic study of lumbar disc herniation in the elderly.

Authors:  Y Harada; S Nakahara
Journal:  Spine (Phila Pa 1976)       Date:  1989-09       Impact factor: 3.468

3.  Lumbar disc degeneration: correlation with age, sex, and spine level in 600 autopsy specimens.

Authors:  J A Miller; C Schmatz; A B Schultz
Journal:  Spine (Phila Pa 1976)       Date:  1988-02       Impact factor: 3.468

4.  Swelling pressure of the lumbar intervertebral discs: influence of age, spinal level, composition, and degeneration.

Authors:  J P Urban; J F McMullin
Journal:  Spine (Phila Pa 1976)       Date:  1988-02       Impact factor: 3.468

5.  The lumbar disc herniation. A computer-aided analysis of 2,504 operations.

Authors:  E V Spangfort
Journal:  Acta Orthop Scand Suppl       Date:  1972

6.  Lumbar disc herniation in the elderly.

Authors:  G L Maistrelli; P A Vaughan; D C Evans; T W Barrington
Journal:  Spine (Phila Pa 1976)       Date:  1987 Jan-Feb       Impact factor: 3.468

7.  Enzymatic digestion of the nucleus pulposus: a review of experimental studies with chymopapain.

Authors:  P J Garvin; R B Jennings; I J Stern
Journal:  Orthop Clin North Am       Date:  1977-01       Impact factor: 2.472

8.  Chymopapain for the treatment of intervertebral disc herniation. A preliminary report of a double-blind study.

Authors:  R D Fraser
Journal:  Spine (Phila Pa 1976)       Date:  1982 Nov-Dec       Impact factor: 3.468

9.  Biochemical changes in intervertebral disc degeneration.

Authors:  G Lyons; S M Eisenstein; M B Sweet
Journal:  Biochim Biophys Acta       Date:  1981-04-03

10.  Safety and efficacy of chymopapain (Discase) in the treatment of sciatica due to a herniated nucleus pulposus. Results of a randomized, double-blind study.

Authors:  E J Dabezies; K Langford; J Morris; C B Shields; H A Wilkinson
Journal:  Spine (Phila Pa 1976)       Date:  1988-05       Impact factor: 3.468

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